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1. Human genetic variant E756del in the ion channel PIEZO1 not associated with protection from severe malaria in a large Ghanaian study.

Author

Thye T, Evans JA, Ruge G, Loag W, Ansong D, Agbenyega T, Horstmann RD, May J, and Schuldt K

Subjects
Adolescent, Adult, Aged, Aged, 80 and over, Alleles, Case-Control Studies, Child, Female, Genotype, Ghana, Humans, Malaria diagnosis, Malaria parasitology, Male, Middle Aged, Severity of Illness Index, Young Adult, Disease Resistance genetics, Genetic Association Studies methods, Genetic Predisposition to Disease, Ion Channels genetics, Malaria genetics, Sequence Deletion
Abstract

Recently, a common genetic variant E756del in the human gene PIEZO1 was associated with protection from severe malaria. Here, we performed a genetic association study of this gain-of-function variant in a large case-control study including 4149 children from the Ashanti Region in Ghana, West Africa. The statistical analysis did not indicate an association with protection from severe malaria and, thus, providing evidence against a strong protective effect of the PIEZO1 E756del variant on severe malaria susceptibility., (© 2021. The Author(s).)

Published
2022
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