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Your search keyword '"Polyketide Synthases physiology"' showing total 2 results
Start Over Descriptor "Polyketide Synthases physiology" Publisher nature pub. group
2 results on '"Polyketide Synthases physiology"'

1. Activation of silent biosynthetic gene clusters using transcription factor decoys.

Author

Wang B, Guo F, Dong SH, and Zhao H

Subjects
Gene Expression Regulation genetics, Multigene Family physiology, Peptide Synthases physiology, Polyketide Synthases physiology, Streptomycetaceae metabolism, Peptide Synthases genetics, Polyketide Synthases genetics, Transcription Factors biosynthesis
Abstract

Here we report a transcription factor decoy strategy for targeted activation of eight large silent polyketide synthase and non-ribosomal peptide synthetase gene clusters, ranging from 50 to 134 kilobases (kb) in multiple streptomycetes, and characterization of a novel oxazole family compound produced by a 98-kb biosynthetic gene cluster. Owing to its simplicity and ease of use, this strategy can be scaled up readily for discovery of natural products in streptomycetes.

Published
2019
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2. Biosynthesis: a twist in the tail.

Author

Weissman KJ

Subjects
Biosynthetic Pathways, Catalysis, Cyclization, Molecular Structure, Polyketide Synthases biosynthesis, Polyketide Synthases genetics, Stereoisomerism, Streptomyces enzymology, Streptomyces genetics, Streptomyces metabolism, Macrolides chemistry, Polyketide Synthases physiology, Pyrans chemistry, Spiro Compounds chemistry
Published
2011
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