Search

Your search keyword '"Yunku Yeu"' showing total 2 results
Start Over Author "Yunku Yeu" Publisher nature portfolio
2 results on '"Yunku Yeu"'

1. Induced organoids derived from patients with ulcerative colitis recapitulate colitic reactivity

Author

Samaneh K. Sarvestani, Steven Signs, Bo Hu, Yunku Yeu, Hao Feng, Ying Ni, David R. Hill, Robert C. Fisher, Sylvain Ferrandon, Reece K. DeHaan, Jennifer Stiene, Michael Cruise, Tae Hyun Hwang, Xiling Shen, Jason R. Spence, and Emina H. Huang

Subjects
Science
Abstract

Although ulcerative colitis (UC) is a major type of inflammatory bowel disease, attempts to model it fully have fallen short. Here the authors use patient-derived iPS cells to develop a UC organoid model that recapitulates disease histological and functional features, and confirm the role of CXCL8/CXCR1 in pathogenesis.

Published
2021
Full Text
View/download PDF

2. CRISPR-Cas9-based mutagenesis frequently provokes on-target mRNA misregulation

Author

Rubina Tuladhar, Yunku Yeu, John Tyler Piazza, Zhen Tan, Jean Rene Clemenceau, Xiaofeng Wu, Quinn Barrett, Jeremiah Herbert, David H. Mathews, James Kim, Tae Hyun Hwang, and Lawrence Lum

Subjects
Science
Abstract

CRISPR-Cas9 genome editing is presumed to knock out gene function by generating a frameshift during NHEJ repair. Here, the authors investigate mRNA and protein expression in edited lines and find genome editing can generate internal ribosome entry sites or alternatively spliced variants.

Published
2019
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results