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A T/C variant in miR-27a is associated with bipolar disorder, potentially by reducing the ability of this microRNA to target important neurodevelopmental genes like NCAM1.

Abstract In low mountain and hilly regions, vegetation cover is higher and plant growth has an accumulative effect, sequestering carbon more strongly. The traditional remote sensing based ecological index (RSEI) lacks the consideration of vegetation productivity, and using it to evaluate ecological environment in low mountain and hilly regions will be biased. In this study, the vegetation productivity was introduced to construct a natural remote sensing based ecological index (NRSEI) that responds to the low mountain and hilly regions, as an example of Gaizhou City, China. Additionally, this study explored the spatiotemporal evolution of ecological environment quality from 2014 to 2020 and quantified the influences of factors. The results show that the first principal component (PC1) increased from 56 to 67% to 65–87% and considered the accumulation process in the ecosystem. NRSEI was more valid. From 2014 to 2020, the quality of the ecological environment generally declined and then increased. The area with “Excellent” increased from 23 to 38%. The quality of ecosystems in the west, northwest, and south deteriorated significantly, a distribution pattern of “high in the center, low in the north and south”. Landuse and topographic conditions dominate the impacts on the ecosystem in the context of social, economic and policy influences. The interactions of the factors were two-factor enhancement that together affect the ecological environment. The results contribute to the development of urban conservation policies in low mountain and hilly regions.

Abstract CO2 hydrogenation to chemicals and fuels is a significant approach for achieving carbon neutrality. It is essential to rationally design the chemical structure and catalytic active sites towards the development of efficient catalysts. Here we show a Ce-CuZn catalyst with enriched Cu/Zn-OV-Ce active sites fabricated through the atomic-level substitution of Cu and Zn into Ce-MOF precursor. The Ce-CuZn catalyst exhibits a high methanol selectivity of 71.1% and a space-time yield of methanol up to 400.3 g·kgcat −1·h−1 with excellent stability for 170 h at 260 °C, comparable to that of the state-of-the-art CuZnAl catalysts. Controlled experiments and DFT calculations confirm that the incorporation of Cu and Zn into CeO2 with abundant oxygen vacancies can facilitate H2 dissociation energetically and thus improve CO2 hydrogenation over the Ce-CuZn catalyst via formate intermediates. This work offers an atomic-level design strategy for constructing efficient multi-metal catalysts for methanol synthesis through precise control of active sites.

Abstract For pre-operative osteoarthritis (OA) patients with varus knee, previous studies showed inconsistent results. Therefore, we conducted this study to better identify the association of Hospital for Special Surgery (HSS) score and mechanical alignment. 44 patients (51 knees) with constitutional varus knee caused by combined deformities (LDFA (lateral distal femoral angle) > 90°and MPTA (medial proximal tibial angle)