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1. Increased slow dynamics defines ligandability of BTB domains

Author

Vladlena Kharchenko, Brian M. Linhares, Megan Borregard, Iwona Czaban, Jolanta Grembecka, Mariusz Jaremko, Tomasz Cierpicki, and Łukasz Jaremko

Subjects
Science
Abstract

Here, the authors discover that ligandability of BTB domains correlates with the presence of μs-ms time scale dynamics. This finding suggests that protein dynamics may be a broadly applicable tool in drug discovery to assess the ligandability of novel and challenging targets.

Published
2022
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