1. Efficacy and safety of TiF4 varnish in preventing erosive tooth wear in a rat animal model
- Author
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Mariele Vertuan, Júlia França da Silva, Aline Dionizio, Beatriz Martines de Souza, Victor Mosquim, Tatiana Martini, Gustavo Pompermaier Garlet, Samira Helena Niemeyer, Marcella Esteves-Oliveira, and Ana Carolina Magalhães
- Subjects
Erosion ,Fluoride ,Tooth erosion ,Titanium ,Medicine ,Science - Abstract
Abstract An animal model was applied to develop erosive tooth wear (ETW) and to evaluate the efficacy and safety of titanium tetrafluoride (TiF4) in preventing ETW. Forty-eight male Wistar rats were divided into three groups (n = 16): TiF4 (2.45% F−), NaF (2.45% F−) and placebo varnishes. Eight from each group were subjected to erosive challenges (Sprite Zero) and the other received tap water, both ad libitum. After twenty-eight days, the mandibles were resected for histopathological gingival analysis, clinical and microscopic tooth evaluation by 3D confocal laser microscopy, scanning electron microscopy (SEM-EDX) and micro-Raman spectroscopy (MRS). Organs were evaluated with respect to fluoride content. No significant difference was found in F content in tissues. No histopathological damage was seen in gingiva. ETW was clinically more aggressive in rats from placebo group consuming Sprite compared to water (Q²=12.6, p
- Published
- 2024
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