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2 results on '"Stephanie Mok"'

1. Mapping cellular-scale internal mechanics in 3D tissues with thermally responsive hydrogel probes

Author

Stephanie Mok, Sara Al Habyan, Charles Ledoux, Wontae Lee, Katherine N. MacDonald, Luke McCaffrey, and Christopher Moraes

Subjects
Science
Abstract

Local mechanical properties are important to cellular function; but conventional measurement techniques are limited in intact, living, 3D tissues. Here, the authors report on swellable hydrogel microparticles to monitor mechanical properties in situ via a temperature change.

Published
2020
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2. Dispersible hydrogel force sensors reveal patterns of solid mechanical stress in multicellular spheroid cultures

Author

Wontae Lee, Nikita Kalashnikov, Stephanie Mok, Ruba Halaoui, Elena Kuzmin, Andrew J. Putnam, Shuichi Takayama, Morag Park, Luke McCaffrey, Ruogang Zhao, Richard L. Leask, and Christopher Moraes

Subjects
Science
Abstract

Understanding how forces orchestrate tissue formation requires technologies to map internal tissue stress at cellular length scales. Here, authors develop ultrasoft sensors that visibly deform under cell-generated stress to capture patterns of internal stress development during multicellular spheroid formation.

Published
2019
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