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Your search keyword '"Silvia Pietrobono"' showing total 2 results
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2 results on '"Silvia Pietrobono"'

1. CCL3 predicts exceptional response to TGFβ inhibition in basal-like pancreatic cancer enriched in LIF-producing macrophages

Author

Silvia Pietrobono, Monica Bertolini, Veronica De Vita, Fabio Sabbadini, Federica Fazzini, Cristina Frusteri, Enza Scarlato, Domenico Mangiameli, Alberto Quinzii, Simona Casalino, Camilla Zecchetto, Valeria Merz, and Davide Melisi

Subjects
Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract

Abstract The TGFβ receptor inhibitor galunisertib showed promising efficacy in patients with pancreatic ductal adenocarcinoma (PDAC) in the phase 2 H9H-MC-JBAJ study. Identifying biomarkers for this treatment remains essential. Baseline plasma levels of chemokine CCL3 were integrated with clinical outcomes in PDAC patients treated with galunisertib plus gemcitabine (n = 104) or placebo plus gemcitabine (n = 52). High CCL3 was a poor prognostic factor in the placebo group (mOS 3.6 vs. 10.1 months; p

Published
2024
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2. ST3GAL1 is a target of the SOX2-GLI1 transcriptional complex and promotes melanoma metastasis through AXL

Author

Silvia Pietrobono, Giulia Anichini, Cesare Sala, Fabrizio Manetti, Luciana L. Almada, Sara Pepe, Ryan M. Carr, Brooke D. Paradise, Jann N. Sarkaria, Jaime I. Davila, Lorenzo Tofani, Ilaria Battisti, Giorgio Arrigoni, Li Ying, Cheng Zhang, Hu Li, Alexander Meves, Martin E. Fernandez-Zapico, and Barbara Stecca

Subjects
Science
Abstract

Understanding the molecular events controlling melanoma progression are necessary to find improved therapeutics. Here, the authors report oncogenic SOX2-GLI1 transcriptional complex to drive melanoma invasion through the induction of the sialyltransferase ST3GAL1, and report ST3GAL1-AXL axis as driver of melanoma metastasis.

Published
2020
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