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Your search keyword '"Salvatore AL"' showing total 6 results
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6 results on '"Salvatore AL"'

1. A phase I study of an adenoviral vector delivering a MUC1/CD40-ligand fusion protein in patients with advanced adenocarcinoma

Author

Tira J. Tan, W. X. Gladys Ang, Who-Whong Wang, Hui-Shan Chong, Sze Huey Tan, Rachael Cheong, John Whay-Kuang Chia, Nicholas L. Syn, Wai Ho Shuen, Rebecca Ba, Nivashini Kaliaperumal, Bijin Au, Richard Hopkins, Xinhua Li, Aaron C. Tan, Amanda O. L. Seet, John E. Connolly, Thaschawee Arkachaisri, Valerie Chew, Ahmad bin Mohamed Lajam, Dianyan Guo, Marvin Z. W. Chew, Martin Wasser, Pavanish Kumar, Salvatore Albani, and Han Chong Toh

Subjects
Science
Abstract

Ad-sig-hMUC1/ecdCD40L is a recombinant adenovirus vaccine comprising human MUC1 antigen fused to the extracellular domain of the CD40 ligand. Here the authors report the result of a phase I clinical trial of Ad-sig-hMUC1/ecdCD40L in patients with advanced adenocarcinoma.

Published
2022
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2. Trajectory of immune evasion and cancer progression in hepatocellular carcinoma

Author

Phuong H. D. Nguyen, Martin Wasser, Chong Teik Tan, Chun Jye Lim, Hannah L. H. Lai, Justine Jia Wen Seow, Ramanuj DasGupta, Cheryl Z. J. Phua, Siming Ma, Jicheng Yang, Sheena D/O Suthen, Wai Leong Tam, Tony K. H. Lim, Joe Yeong, Wei Qiang Leow, Yin Huei Pang, Gwyneth Soon, Tracy Jiezhen Loh, Wei Keat Wan, Chung Yip Chan, Peng Chung Cheow, Han Chong Toh, Alfred Kow, Yock Young Dan, Juinn Huar Kam, Shridhar Iyer, Krishnakumar Madhavan, Alexander Chung, Glenn K. Bonney, Brian K. P. Goh, Naiyang Fu, Victor C. Yu, Weiwei Zhai, Salvatore Albani, Pierce K. H. Chow, and Valerie Chew

Subjects
Science
Abstract

In order to design cancer immune therapies, it is important to understand how tumours evade the immune response that is mounted against them. Authors here analyse the distribution and properties of immune cells in hepatocellular carcinoma and describe a progressive tumour-immune co-evolution programme from early to late stage cancer.

Published
2022
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3. AKT3-mediated IWS1 phosphorylation promotes the proliferation of EGFR-mutant lung adenocarcinomas through cell cycle-regulated U2AF2 RNA splicing

Author

Georgios I. Laliotis, Evangelia Chavdoula, Maria D. Paraskevopoulou, Abdul Kaba, Alessandro La Ferlita, Satishkumar Singh, Vollter Anastas, Keith A. Nair, Arturo Orlacchio, Vasiliki Taraslia, Ioannis Vlachos, Marina Capece, Artemis Hatzigeorgiou, Dario Palmieri, Christos Tsatsanis, Salvatore Alaimo, Lalit Sehgal, David P. Carbone, Vincenzo Coppola, and Philip N. Tsichlis

Subjects
Science
Abstract

IWS1 regulates multiple steps in RNA metabolism, including RNA elongation and alternative RNA splicing. Here the authors show that AKT3 phosphorylates IWS1, which alters U2AF2 RNA splicing and promotes growth of lung adenocarcinomas via a Sororin/ERK-dependent pathway.

Published
2021
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4. Intratumoural immune heterogeneity as a hallmark of tumour evolution and progression in hepatocellular carcinoma

Author

Phuong H. D. Nguyen, Siming Ma, Cheryl Z. J. Phua, Neslihan A. Kaya, Hannah L. H. Lai, Chun Jye Lim, Jia Qi Lim, Martin Wasser, Liyun Lai, Wai Leong Tam, Tony K. H. Lim, Wei Keat Wan, Tracy Loh, Wei Qiang Leow, Yin Huei Pang, Chung Yip Chan, Ser Yee Lee, Peng Chung Cheow, Han Chong Toh, Florent Ginhoux, Shridhar Iyer, Alfred W. C. Kow, Yock Young Dan, Alexander Chung, Brian K. P. Goh, Salvatore Albani, Pierce K. H. Chow, Weiwei Zhai, and Valerie Chew

Subjects
Science
Abstract

Intratumoural heterogeneity is a feature of liver cancer. Here, the authors demonstrate that heterogeneity exists at the immune cell level in liver cancer and show that tumours with high intratumoural immune heterogeneity demonstrated an immune suppressive microenvironment, which was associated with tumour evolution and a poor prognosis.

Published
2021
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5. Retraction Note: AKT3-mediated IWS1 phosphorylation promotes the proliferation of EGFR-mutant lung adenocarcinomas through cell cycle-regulated U2AF2 RNA splicing

Author

Georgios I. Laliotis, Evangelia Chavdoula, Maria D. Paraskevopoulou, Abdul Kaba, Alessandro La Ferlita, Satishkumar Singh, Vollter Anastas, Keith A. Nair, Arturo Orlacchio, Vasiliki Taraslia, Ioannis Vlachos, Marina Capece, Artemis Hatzigeorgiou, Dario Palmieri, Christos Tsatsanis, Salvatore Alaimo, Lalit Sehgal, David P. Carbone, Vincenzo Coppola, and Philip N. Tsichlis

Subjects
Science
Published
2022
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6. Author Correction: Intratumoural immune heterogeneity as a hallmark of tumour evolution and progression in hepatocellular carcinoma

Author

Phuong H. D. Nguyen, Siming Ma, Cheryl Z. J. Phua, Neslihan A. Kaya, Hannah L. H. Lai, Chun Jye Lim, Jia Qi Lim, Martin Wasser, Liyun Lai, Wai Leong Tam, Tony K. H. Lim, Wei Keat Wan, Tracy Loh, Wei Qiang Leow, Yin Huei Pang, Chung Yip Chan, Ser Yee Lee, Peng Chung Cheow, Han Chong Toh, Florent Ginhoux, Shridhar Iyer, Alfred W. C. Kow, Yock Young Dan, Alexander Chung, Glen K. Bonney, Brian K. P. Goh, Salvatore Albani, Pierce K. H. Chow, Weiwei Zhai, and Valerie Chew

Subjects
Science
Abstract

A Correction to this paper has been published: https://doi.org/10.1038/s41467-021-21556-y.

Published
2021
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