1. Prognostic impact of lymphovascular and perineural invasion in squamous cell carcinoma of the tongue
- Author
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Qiongling Huang, Yanjun Huang, Chunhui Chen, Yizheng Zhang, Jiao Zhou, Chengke Xie, Ming Lu, Yu Xiong, Dage Fang, Yubin Yang, Weipeng Hu, Feng Zheng, and Chaohui Zheng
- Subjects
Medicine ,Science - Abstract
Abstract This study aimed to investigate the prognostic impact of lymphovascular and perineural invasions in patients with squamous cell carcinoma of the tongue who received surgery-based treatment at our institution between January 2013 and December 2020. Patients were divided into four groups based on the presence of perineural (P−/P +) and lymphovascular invasions (V−/V +): P–V−, P–V + , P + V−, and P + V + . Log-rank and Cox proportional hazard models were used to evaluate the association between perineural /lymphovascular invasion and overall survival (OS). Altogether, 127 patients were included, and 95 (74.8%), 8 (6.3%), 18 (14.2%), and 6 (4.7%) cases were classified as P–V−, P–V + , P + V−, and P + V + , respectively. Pathologic N stage (pN stage), tumor stage, histological grade, lymphovascular invasion, perineural invasion, and postoperative radiotherapy were significantly associated with OS (p
- Published
- 2023
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