Search

Your search keyword '"Orsi Giricz"' showing total 1 results
Start Over Author "Orsi Giricz" Publisher nature portfolio
1 results on '"Orsi Giricz"'

1. Inhibitors of BRAF dimers using an allosteric site

Author

Xiomaris M. Cotto-Rios, Bogos Agianian, Nadege Gitego, Emmanouil Zacharioudakis, Orsi Giricz, Yang Wu, Yiyu Zou, Amit Verma, Poulikos I. Poulikakos, and Evripidis Gavathiotis

Subjects
Science
Abstract

FDA-approved RAF inhibitors poorly inhibit BRAF dimers, which limits their clinical efficacy in tumors expressing BRAFV600E mutant monomers. Here the authors identify FDA-approved Ponatinib as an effective inhibitor of BRAF monomers and dimers and designed PHI1, an inhibitor with a unique mode of action and selectivity for oncogenic BRAF dimers.

Published
2020
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results