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1. HOTAIR rs7958904 polymorphism is associated with increased cervical cancer risk in a Chinese population

Author

Hua Jin, Xiaoyun Lu, Jing Ni, Jinfang Sun, Bin Gu, Bo Ding, Haixia Zhu, Chao Ma, Mengjing Cui, Yuling Xu, Zhengdong Zhang, Martin Lercher, Jian Chen, Na Gao, and Shizhi Wang

Subjects
Medicine, Science
Abstract

Abstract Previously, we have identified single nucleotide polymorphisms (SNPs) rs7958904 and rs4759314 in long non-coding RNA HOX transcript antisense RNA (HOTAIR) were significantly associated with risk of colorectal and gastric cancer, respectively. Here, we aimed to investigate the association between HOTAIR SNPs and cervical cancer (CC) susceptibility. A total of 1209 cases and 1348 controls were enrolled for association study and genotyped with TaqMan allelic discrimination method. The Cancer Genome Atlas (TCGA) database was utilized for in vivo analysis of allele-specific HOTAIR expression. MTT assay was employed for evaluation of allele-specific cell proliferation. The rs7958904 CC genotype was related to an increased risk of cervical cancer compared with the GG/GC genotypes (OR = 1.57, 95% CI = 1.10–2.25). TCGA database showed the CC tissues with rs7958904 CC genotype had higher HOTAIR expression than those with GG genotype (P = 0.046). MTT assay demonstrated a growth-promoting role of rs7958904 C allele on CC cells. Further functional studies on the effect of rs7958904 on biological behavior of CC cells are needed to confirm and extend our findings. In conclusion, HOTAIR rs7958904 might influence CC susceptibility through modulation of CC cell proliferation, and could serve as a diagnostic biomarker.

Published
2017
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2. HOTAIR rs7958904 polymorphism is associated with increased cervical cancer risk in a Chinese population

Author

Jinfang Sun, Mengjing Cui, Bin Gu, Xiaoyun Lu, Martin J. Lercher, Chao Ma, Zhengdong Zhang, Yuling Xu, Jing Ni, Shizhi Wang, Haixia Zhu, Hua Jin, Na Gao, Bo Ding, and Jian Chen

Subjects
0301 basic medicine, China, Genotyping Techniques, Science, Uterine Cervical Neoplasms, Single-nucleotide polymorphism, Biology, Bioinformatics, Polymorphism, Single Nucleotide, Article, 03 medical and health sciences, Exon, 0302 clinical medicine, Asian People, Cell Line, Tumor, Genotype, medicine, Humans, Genetic Predisposition to Disease, Allele, Early Detection of Cancer, Genetic Association Studies, Cell Proliferation, Cervical cancer, Multidisciplinary, Case-control study, HOTAIR, Exons, medicine.disease, 030104 developmental biology, 030220 oncology & carcinogenesis, Case-Control Studies, Cancer research, Medicine, Female, RNA, Long Noncoding, HOX Transcript Antisense RNA, HeLa Cells
Abstract

Previously, we have identified single nucleotide polymorphisms (SNPs) rs7958904 and rs4759314 in long non-coding RNA HOX transcript antisense RNA (HOTAIR) were significantly associated with risk of colorectal and gastric cancer, respectively. Here, we aimed to investigate the association between HOTAIR SNPs and cervical cancer (CC) susceptibility. A total of 1209 cases and 1348 controls were enrolled for association study and genotyped with TaqMan allelic discrimination method. The Cancer Genome Atlas (TCGA) database was utilized for in vivo analysis of allele-specific HOTAIR expression. MTT assay was employed for evaluation of allele-specific cell proliferation. The rs7958904 CC genotype was related to an increased risk of cervical cancer compared with the GG/GC genotypes (OR = 1.57, 95% CI = 1.10–2.25). TCGA database showed the CC tissues with rs7958904 CC genotype had higher HOTAIR expression than those with GG genotype (P = 0.046). MTT assay demonstrated a growth-promoting role of rs7958904 C allele on CC cells. Further functional studies on the effect of rs7958904 on biological behavior of CC cells are needed to confirm and extend our findings. In conclusion, HOTAIR rs7958904 might influence CC susceptibility through modulation of CC cell proliferation, and could serve as a diagnostic biomarker.

Published
2017

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