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1. Cytomembrane nanovaccines show therapeutic effects by mimicking tumor cells and antigen presenting cells

Author

Wen-Long Liu, Mei-Zhen Zou, Tao Liu, Jin-Yue Zeng, Xue Li, Wu-Yang Yu, Chu-Xin Li, Jing-Jie Ye, Wen Song, Jun Feng, and Xian-Zheng Zhang

Subjects
Science
Abstract

Cancer vaccines often fail to generate clinically relevant effects. Here, the authors generate a nanosized cytomembrane vaccine based on fusion between dendritic cells and cancer cells, and show them to activate anti-tumor immune responses via their antigen presenting and T-cell activating functions.

Published
2019
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