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1. Prognostic and therapeutic implications of extracellular matrix associated gene signature in renal clear cell carcinoma

Author

Pankaj Ahluwalia, Meenakshi Ahluwalia, Ashis K. Mondal, Nikhil Sahajpal, Vamsi Kota, Mumtaz V. Rojiani, Amyn M. Rojiani, and Ravindra Kolhe

Subjects
Medicine, Science
Abstract

Abstract Complex interactions in tumor microenvironment between ECM (extra-cellular matrix) and cancer cell plays a central role in the generation of tumor supportive microenvironment. In this study, the expression of ECM-related genes was explored for prognostic and immunological implication in clear cell renal clear cell carcinoma (ccRCC). Out of 964 ECM genes, higher expression (z-score > 2) of 35 genes showed significant association with overall survival (OS), progression-free survival (PFS) and disease-specific survival (DSS). On comparison to normal tissue, 12 genes (NUDT1, SIGLEC1, LRP1, LOXL2, SERPINE1, PLOD3, ZP3, RARRES2, TGM2, COL3A1, ANXA4, and POSTN) showed elevated expression in kidney tumor (n = 523) compared to normal (n = 100). Further, Cox proportional hazard model was utilized to develop 12 genes ECM signature that showed significant association with overall survival in TCGA dataset (HR = 2.45; 95% CI [1.78–3.38]; p

Published
2021
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2. Prognostic and therapeutic implications of extracellular matrix associated gene signature in renal clear cell carcinoma

Author

Mumtaz V. Rojiani, Pankaj Ahluwalia, Ashis K. Mondal, Meenakshi Ahluwalia, Ravindra Kolhe, Vamsi Kota, Nikhil Shri Sahajpal, and Amyn M. Rojiani

Subjects
Male, Science, Kaplan-Meier Estimate, Biology, Article, Extracellular matrix, Gene expression, Genetics, medicine, Tumor Microenvironment, Humans, Gene Regulatory Networks, Carcinoma, Renal Cell, Cancer, Aged, Proportional Hazards Models, Tumor microenvironment, Multidisciplinary, LOXL2, Gene signature, Middle Aged, medicine.disease, Prognosis, Fold change, Kidney Neoplasms, Progression-Free Survival, Extracellular Matrix, Gene Expression Regulation, Neoplastic, Cancer research, Medicine, Female, Clear cell
Abstract

Complex interactions in tumor microenvironment between ECM (extra-cellular matrix) and cancer cell plays a central role in the generation of tumor supportive microenvironment. In this study, the expression of ECM-related genes was explored for prognostic and immunological implication in clear cell renal clear cell carcinoma (ccRCC). Out of 964 ECM genes, higher expression (z-score > 2) of 35 genes showed significant association with overall survival (OS), progression-free survival (PFS) and disease-specific survival (DSS). On comparison to normal tissue, 12 genes (NUDT1, SIGLEC1, LRP1, LOXL2, SERPINE1, PLOD3, ZP3, RARRES2, TGM2, COL3A1, ANXA4, and POSTN) showed elevated expression in kidney tumor (n = 523) compared to normal (n = 100). Further, Cox proportional hazard model was utilized to develop 12 genes ECM signature that showed significant association with overall survival in TCGA dataset (HR = 2.45; 95% CI [1.78–3.38]; p

Published
2021

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