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1. Stepwise maturation of the peptidyl transferase region of human mitoribosomes

Author

Tea Lenarčič, Mateusz Jaskolowski, Marc Leibundgut, Alain Scaiola, Tanja Schönhut, Martin Saurer, Richard G. Lee, Oliver Rackham, Aleksandra Filipovska, and Nenad Ban

Subjects
Science
Abstract

Mammalian mitoribosomes feature dramatically reduced ribosomal RNAs and follow mitochondria specific assembly pathways. Here the authors describe the process of human mitochondrial ribosome maturation that results in the formation of the ribosomal active site region, including the peptidyl transferase loop and the two tRNA-binding loops.

Published
2021
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