6 results on '"Lorenzo Massimi"'
Search Results
2. A multi-analytical approach to studying the chemical composition of typical carbon sink samples
- Author
-
Maria Luisa Astolfi, Lorenzo Massimi, Mattia Rapa, Rita Rosa Plà, Raquel Clara Jasan, Mabel Beatriz Tudino, Silvia Canepari, and Marcelo Enrique Conti
- Subjects
Medicine ,Science - Abstract
Abstract Peatlands in southern South America (Tierra del Fuego region, TdF) play a key role in the ecological dynamics of Patagonia. It is, therefore, necessary to increase our knowledge and awareness of their scientific and ecological value to ensure their conservation. This study aimed to assess the differences in the distribution and accumulation of elements in peat deposits and Sphagnum moss from the TdF. Chemical and morphological characterization of the samples was carried out using various analytical techniques, and total levels of 53 elements were determined. Furthermore, a chemometric differentiation based on the elemental content of peat and moss samples was performed. Some elements (Cs, Hf, K, Li, Mn, Na, Pb, Rb, Si, Sn, Ti and Zn) showed significantly higher contents in moss samples than in peat samples. In contrast, only Mo, S and Zr were significantly higher in peat samples than in moss samples. The results obtained highlight the ability of moss to accumulate elements and to act as a means to facilitate the entry of elements into peat samples. The valuable data obtained in this multi-methodological baseline survey can be used for more effective conservation of biodiversity and preservation of the ecosystem services of the TdF.
- Published
- 2023
- Full Text
- View/download PDF
3. Multilevel X-ray imaging approach to assess the sequential evolution of multi-organ damage in multiple sclerosis
- Author
-
Francesca Palermo, Nicola Pieroni, Alessia Sanna, Benedetta Parodi, Consuelo Venturi, Ginevra Begani Provinciali, Lorenzo Massimi, Laura Maugeri, Gian Paolo Marra, Elena Longo, Lorenzo D’Amico, Giulia Saccomano, Jonathan Perrin, Giuliana Tromba, Inna Bukreeva, Michela Fratini, Giuseppe Gigli, Nicole Kerlero de Rosbo, and Alessia Cedola
- Subjects
Astrophysics ,QB460-466 ,Physics ,QC1-999 - Abstract
X-ray phase-contrast tomography offers a highly sensitive 3D imaging approach to investigate different disease-relevant networks at levels ranging from single cell through to intact organ. The authors present a concomitant study of the evolution of tissue damage and inflammation in different organs affected by the disease in the murine model for multiple sclerosis.
- Published
- 2022
- Full Text
- View/download PDF
4. Time resolved in-situ multi-contrast X-ray imaging of melting in metals
- Author
-
Lorenzo Massimi, Samuel J. Clark, Sebastian Marussi, Adam Doherty, Saurabh M. Shah, Joachim Schulz, Shashidhara Marathe, Christoph Rau, Marco Endrizzi, Peter D. Lee, and Alessandro Olivo
- Subjects
Medicine ,Science - Abstract
Abstract In this work, the application of a time resolved multi-contrast beam tracking technique to the investigation of the melting and solidification process in metals is presented. The use of such a technique allows retrieval of three contrast channels, transmission, refraction and dark-field, with millisecond time resolution. We investigated different melting conditions to characterize, at a proof-of-concept level, the features visible in each of the contrast channels. We found that the phase contrast channel provides a superior visibility of the density variations, allowing the liquid metal pool to be clearly distinguished. Refraction and dark-field were found to highlight surface roughness formed during solidification. This work demonstrates that the availability of the additional contrast channels provided by multi-contrast X-ray imaging delivers additional information, also when imaging high atomic number specimens with a significant absorption.
- Published
- 2022
- Full Text
- View/download PDF
5. Detection of involved margins in breast specimens with X-ray phase-contrast computed tomography
- Author
-
Lorenzo Massimi, Tamara Suaris, Charlotte K. Hagen, Marco Endrizzi, Peter R. T. Munro, Glafkos Havariyoun, P. M. Sam Hawker, Bennie Smit, Alberto Astolfo, Oliver J. Larkin, Richard M. Waltham, Zoheb Shah, Stephen W. Duffy, Rachel L. Nelan, Anthony Peel, J. Louise Jones, Ian G. Haig, David Bate, and Alessandro Olivo
- Subjects
Medicine ,Science - Abstract
Abstract Margins of wide local excisions in breast conserving surgery are tested through histology, which can delay results by days and lead to second operations. Detection of margin involvement intraoperatively would allow the removal of additional tissue during the same intervention. X-ray phase contrast imaging (XPCI) provides soft tissue sensitivity superior to conventional X-rays: we propose its use to detect margin involvement intraoperatively. We have developed a system that can perform phase-based computed tomography (CT) scans in minutes, used it to image 101 specimens approximately half of which contained neoplastic lesions, and compared results against those of a commercial system. Histological analysis was carried out on all specimens and used as the gold standard. XPCI-CT showed higher sensitivity (83%, 95% CI 69–92%) than conventional specimen imaging (32%, 95% CI 20–49%) for detection of lesions at margin, and comparable specificity (83%, 95% CI 70–92% vs 86%, 95% CI 73–93%). Within the limits of this study, in particular that specimens obtained from surplus tissue typically contain small lesions which makes detection more difficult for both methods, we believe it likely that the observed increase in sensitivity will lead to a comparable reduction in the number of re-operations.
- Published
- 2021
- Full Text
- View/download PDF
6. Detection of involved margins in breast specimens with X-ray phase-contrast computed tomography
- Author
-
Marco Endrizzi, J. Louise Jones, Alessandro Olivo, Oliver J. Larkin, Stephen W. Duffy, Anthony Peel, Richard M. Waltham, Lorenzo Massimi, Ian Haig, Glafkos Havariyoun, Alberto Astolfo, Peter R. T. Munro, Bennie Smit, Tamara Suaris, Charlotte K. Hagen, P. M. Sam Hawker, Rachel L. Nelan, Zoheb Shah, and David Bate
- Subjects
Cancer therapy ,Phase contrast microscopy ,medicine.medical_treatment ,Science ,Breast Neoplasms ,Computed tomography ,Mastectomy, Segmental ,Article ,Techniques and instrumentation ,030218 nuclear medicine & medical imaging ,law.invention ,03 medical and health sciences ,Breast cancer ,Optical physics ,0302 clinical medicine ,law ,medicine ,Breast-conserving surgery ,Humans ,Microscopy, Phase-Contrast ,Breast ,Cancer ,Multidisciplinary ,medicine.diagnostic_test ,business.industry ,Physics ,X-ray ,Phase-contrast imaging ,Margins of Excision ,Soft tissue ,Histology ,Gold standard (test) ,Radiography ,Applied physics ,Optics and photonics ,030220 oncology & carcinogenesis ,Medicine ,Female ,Cancer imaging ,Tomography, X-Ray Computed ,business ,Nuclear medicine ,Biomedical engineering - Abstract
Margins of wide local excisions in breast conserving surgery are tested through histology, which can delay results by days and lead to second operations. Detection of margin involvement intraoperatively would allow the removal of additional tissue during the same intervention. X-ray phase contrast imaging (XPCI) provides soft tissue sensitivity superior to conventional X-rays: we propose its use to detect margin involvement intraoperatively. We have developed a system that can perform phase-based computed tomography (CT) scans in minutes, used it to image 101 specimens approximately half of which contained neoplastic lesions, and compared results against those of a commercial system. Histological analysis was carried out on all specimens and used as the gold standard. XPCI-CT showed higher sensitivity (83%, 95% CI 69–92%) than conventional specimen imaging (32%, 95% CI 20–49%) for detection of lesions at margin, and comparable specificity (83%, 95% CI 70–92% vs 86%, 95% CI 73–93%). Within the limits of this study, in particular that specimens obtained from surplus tissue typically contain small lesions which makes detection more difficult for both methods, we believe it likely that the observed increase in sensitivity will lead to a comparable reduction in the number of re-operations.
- Published
- 2021
Catalog
Discovery Service for Jio Institute Digital Library
For full access to our library's resources, please sign in.