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1. JMJD3 facilitates C/EBPβ-centered transcriptional program to exert oncorepressor activity in AML

Author

Shan-He Yu, Kang-Yong Zhu, Juan Chen, Xiang-Zhen Liu, Peng-Fei Xu, Wu Zhang, Li Yan, He-Zhou Guo, and Jiang Zhu

Subjects
Science
Abstract

Histone demethylase JMJD3 is known to be oncogenic in preleukemic states and T-cell acute lymphocytic leukemia. Here, the authors show that in some acute myeloid leukemia subsets, JMJD3 can actually act as a potential oncorepressor via mediation of C/EBPβ-centered transcriptional programming.

Published
2018
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