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1. Immune-mediated tubule atrophy promotes acute kidney injury to chronic kidney disease transition

Author

Leyuan Xu, Jiankan Guo, Dennis G. Moledina, and Lloyd G. Cantley

Subjects
Science
Abstract

Acute kidney injury can lead to chronic kidney disease. Here the authors show that the transition is related to a macrophage-mediated second wave of inflammatory cells that promote late tubule injury, dedifferentiation and fibrosis. Suppressing this second wave reduced tubular loss and kidney atrophy.

Published
2022
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