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Your search keyword '"Jean-Sébastien Hoffmann"' showing total 4 results
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4 results on '"Jean-Sébastien Hoffmann"'

1. Overexpression of Claspin and Timeless protects cancer cells from replication stress in a checkpoint-independent manner

Author

Julien N. Bianco, Valérie Bergoglio, Yea-Lih Lin, Marie-Jeanne Pillaire, Anne-Lyne Schmitz, Julia Gilhodes, Amelie Lusque, Julien Mazières, Magali Lacroix-Triki, Theodoros I. Roumeliotis, Jyoti Choudhary, Jérôme Moreaux, Jean-Sébastien Hoffmann, Hélène Tourrière, and Philippe Pasero

Subjects
Science
Abstract

Oncogene-induced replication stress (RS) promotes cancer development. Here, the authors report that cancer cells adapt to oncogene-induced RS by overexpressing downstream components of ATR-CHK1 pathway, Claspin and Timeless, which have protective role at the replication forks independent of their checkpoint function.

Published
2019
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2. MUS81 nuclease activity is essential for replication stress tolerance and chromosome segregation in BRCA2-deficient cells

Author

Xianning Lai, Ronan Broderick, Valérie Bergoglio, Jutta Zimmer, Sophie Badie, Wojciech Niedzwiedz, Jean-Sébastien Hoffmann, and Madalena Tarsounas

Subjects
Science
Abstract

BRCA2-deficient cells fail to complete replication in S-phase, which results in DNA bridges and chromosome mis-segregation at mitosis. Here the authors show that MUS81 helps BRCA2-deficient cells survive replication stress by activating mitotic DNA synthesis and resolving mitotic DNA bridges.

Published
2017
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3. Correction: Corrigendum: MUS81 nuclease activity is essential for replication stress tolerance and chromosome segregation in BRCA2-deficient cells

Author

Xianning Lai, Ronan Broderick, Valérie Bergoglio, Jutta Zimmer, Sophie Badie, Wojciech Niedzwiedz, Jean-Sébastien Hoffmann, and Madalena Tarsounas

Subjects
Science
Abstract

Nature Communications 8: Article number: 15983 (2017); Published: 17 July 2017; Updated: 26 October 2017 In this Article, there are errors in the labelling of the y axis in Fig. 1a and Supplementary Fig. 1b. The labels ‘20’, ‘40’, ‘60’, ‘80’ and ‘100’ should have been ‘0.5’, ‘1.0’ and ‘1.5’ in Fig. 1a and the labels ‘50’, ‘100’, ‘150’ and ‘200’ should have been ‘1’, ‘2’ and ‘3’ in Supplementary Fig.

Published
2017
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4. Correction: Corrigendum: MUS81 nuclease activity is essential for replication stress tolerance and chromosome segregation in BRCA2-deficient cells

Author

Valérie Bergoglio, Wojciech Niedzwiedz, Ronan Broderick, Sophie Badie, Jutta Zimmer, Madalena Tarsounas, Jean-Sébastien Hoffmann, and Xianning Lai

Subjects
0301 basic medicine, Genetics, Nuclease, Multidisciplinary, Replication stress, biology, Science, General Physics and Astronomy, General Chemistry, MUS81, General Biochemistry, Genetics and Molecular Biology, Chromosome segregation, 03 medical and health sciences, 030104 developmental biology, biology.protein
Abstract

Nature Communications 8: Article number: 15983 (2017); Published: 17 July 2017; Updated: 26 October 2017 In this Article, there are errors in the labelling of the y axis in Fig. 1a and Supplementary Fig. 1b. The labels ‘20’, ‘40’, ‘60’, ‘80’ and ‘100’ should have been ‘0.5’, ‘1.0’ and ‘1.5’ in Fig. 1a and the labels ‘50’, ‘100’, ‘150’ and ‘200’ should have been ‘1’, ‘2’ and ‘3’ in Supplementary Fig.

Published
2017

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