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1. Spatial oxidation of L-plastin downmodulates actin-based functions of tumor cells

Author

Emre Balta, Robert Hardt, Jie Liang, Henning Kirchgessner, Christian Orlik, Beate Jahraus, Stefan Hillmer, Stefan Meuer, Katrin Hübner, Guido H. Wabnitz, and Yvonne Samstag

Subjects
Science
Abstract

The actin-remodelling protein L-plastin promotes tumour migration and invasion. Here, the authors show that L-plastin is regulated spatially by ROS-induced thiol oxidation which inhibits its actin-bundling function and cell spreading and filopodial extension formation in tumor cells.

Published
2019
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