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1. Detection of genetic variation and base modifications at base-pair resolution on both DNA and RNA

Author

Zhen Wang, Jérôme Maluenda, Laurène Giraut, Thibault Vieille, Andréas Lefevre, David Salthouse, Gaël Radou, Rémi Moulinas, Sandra Astete, Pol D’Avezac, Geoff Smith, Charles André, Jean-François Allemand, David Bensimon, Vincent Croquette, Jimmy Ouellet, and Gordon Hamilton

Subjects
Biology (General), QH301-705.5
Abstract

Wang et al. show how genetic sequence and base modifications can be detected simultaneously on single molecules of both DNA and RNA using magnetic tweezers. They also demonstrate an amplification-free CRISPR/Cas9-based strategy for isolating target regions from native DNA and apply this approach to the isolation of targets from E. coli and human genomic DNA.

Published
2021
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2. Publisher Correction: Detection of genetic variation and base modifications at base-pair resolution on both DNA and RNA

Author

Zhen Wang, Jérôme Maluenda, Laurène Giraut, Thibault Vieille, Andréas Lefevre, David Salthouse, Gaël Radou, Rémi Moulinas, Sandra Astete, Pol D’Avezac, Geoff Smith, Charles André, Jean-François Allemand, David Bensimon, Vincent Croquette, Jimmy Ouellet, and Gordon Hamilton

Subjects
Biology (General), QH301-705.5
Abstract

A Correction to this paper has been published: https://doi.org/10.1038/s42003-021-01894-9

Published
2021
Full Text
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