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1. Stimulation of CRISPR-mediated homology-directed repair by an engineered RAD18 variant

Author

Tarun S. Nambiar, Pierre Billon, Giacomo Diedenhofen, Samuel B. Hayward, Angelo Taglialatela, Kunheng Cai, Jen-Wei Huang, Giuseppe Leuzzi, Raquel Cuella-Martin, Andrew Palacios, Anuj Gupta, Dieter Egli, and Alberto Ciccia

Subjects
Science
Abstract

Manipulating DNA repair pathways can be used to improve the outcomes of CRISPR-based genome editing. Here the authors derive an enhanced RAD18 variant that suppresses 53BP1 recruitment to DNA double-strand breaks to enhance homology-mediated repair.

Published
2019
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