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1. Secondary metabolites changes in germinated barley and its relationship to anti-wrinkle activity

Author

Sang Cheol Park, Qianwen Wu, Eun-yi Ko, Ji Hwoon Baek, Jeoungjin Ryu, Seunghyun Kang, Mi Kyung Sung, Ah-Reum Cho, and Young Pyo Jang

Subjects
Medicine, Science
Abstract

Abstract The purpose of this research was to identify metabolite change during barley (Hordeum vulgare) germination and reveal active principles for the anti-wrinkle activity. Barley was germinated with deionized water (DW) and mineral-rich water (MRW) for the comparison of the effect of mineral contents on the metabolites changes during germination. The effects of germinated barley extracts (GBEs) on collagen production and collagenase inhibition were evaluated in vitro using human dermal fibroblasts (HDFs). A pronounced anti-wrinkle activity was observed in the test group treated with the MRW-GBEs. In order to find out the active components related to the anti-wrinkle activity, an orthogonal projection to latent structure-discriminant analysis (OPLS-DA) was performed, using the data from secondary metabolites profiling conducted by UPLC–PDA–ESI–MS. The anti-wrinkle activity of MRW-GBEs was revealed to be associated with the increase of oligomeric compounds of procyanidin and prodelphinidin, indicating that it can be used as an active ingredient for anti-wrinkle agents.

Published
2021
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2. Secondary metabolites changes in germinated barley and its relationship to anti-wrinkle activity

Author

Jeoungjin Ryu, Ah-Reum Cho, Mi Kyung Sung, Seunghyun Kang, Ji Hwoon Baek, Sang Cheol Park, Qianwen Wu, Young Pyo Jang, and Eun-yi Ko

Subjects
Statistical methods, Metabolite, Science, Germination, 01 natural sciences, Article, Collagen Type I, chemistry.chemical_compound, medicine, Humans, Food science, Cells, Cultured, Active ingredient, Multidisciplinary, Plant Extracts, 010405 organic chemistry, Chemistry, 010401 analytical chemistry, food and beverages, Hordeum, Dermis, Fibroblasts, In vitro, Skin Aging, 0104 chemical sciences, Proanthocyanidin, Metabolome, Collagenase, Medicine, Hordeum vulgare, Secondary metabolism, Matrix Metalloproteinase 1, Prodelphinidin, medicine.drug
Abstract

The purpose of this research was to identify metabolite change during barley (Hordeum vulgare) germination and reveal active principles for the anti-wrinkle activity. Barley was germinated with deionized water (DW) and mineral-rich water (MRW) for the comparison of the effect of mineral contents on the metabolites changes during germination. The effects of germinated barley extracts (GBEs) on collagen production and collagenase inhibition were evaluated in vitro using human dermal fibroblasts (HDFs). A pronounced anti-wrinkle activity was observed in the test group treated with the MRW-GBEs. In order to find out the active components related to the anti-wrinkle activity, an orthogonal projection to latent structure-discriminant analysis (OPLS-DA) was performed, using the data from secondary metabolites profiling conducted by UPLC–PDA–ESI–MS. The anti-wrinkle activity of MRW-GBEs was revealed to be associated with the increase of oligomeric compounds of procyanidin and prodelphinidin, indicating that it can be used as an active ingredient for anti-wrinkle agents.

Published
2021

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