Search

Your search keyword '"Cuiping Tian"' showing total 3 results
Start Over Author "Cuiping Tian" Publisher nature portfolio
3 results on '"Cuiping Tian"'

1. Organized cannabinoid receptor distribution in neurons revealed by super-resolution fluorescence imaging

Author

Hui Li, Jie Yang, Cuiping Tian, Min Diao, Quan Wang, Simeng Zhao, Shanshan Li, Fangzhi Tan, Tian Hua, Ya Qin, Chao-Po Lin, Dylan Deska-Gauthier, Garth J. Thompson, Ying Zhang, Wenqing Shui, Zhi-Jie Liu, Tong Wang, and Guisheng Zhong

Subjects
Science
Abstract

Despite the importance of G-protein-coupled receptors in many cellular functions, their intracellular organisation is largely unknown. The authors identified periodically repeating clusters of cannabinoid receptor 1 hotspots within neuronal axons that are dynamically regulated by CB1 agonists.

Published
2020
Full Text
View/download PDF

2. Second messenger Ap4A polymerizes target protein HINT1 to transduce signals in FcεRI-activated mast cells

Author

Jing Yu, Zaizhou Liu, Yuanyuan Liang, Feng Luo, Jie Zhang, Cuiping Tian, Alex Motzik, Mengmeng Zheng, Jingwu Kang, Guisheng Zhong, Cong Liu, Pengfei Fang, Min Guo, Ehud Razin, and Jing Wang

Subjects
Science
Abstract

The second messenger Ap4A contributes to mast cell activation by interacting with HINT1 but the molecular mechanism is not fully understood. Here, the authors show that Ap4A regulates downstream signaling by polymerizing HINT1 and provide insights into how specificity over other second messengers is achieved.

Published
2019
Full Text
View/download PDF

3. Organized cannabinoid receptor distribution in neurons revealed by super-resolution fluorescence imaging

Author

Jie Yang, Shanshan Li, Simeng Zhao, Tong Wang, Min Diao, Cuiping Tian, Zhi-Jie Liu, Fangzhi Tan, Tian Hua, Garth John Thompson, Ying Zhang, Chao-Po Lin, Dylan Deska-Gauthier, Wenqing Shui, Guisheng Zhong, Ya Qin, Hui Li, and Quan Wang

Subjects
Male, 0301 basic medicine, Agonist, Fluorescence-lifetime imaging microscopy, Cannabinoid receptor, medicine.drug_class, medicine.medical_treatment, Science, General Physics and Astronomy, Article, General Biochemistry, Genetics and Molecular Biology, Rats, Sprague-Dawley, 03 medical and health sciences, 0302 clinical medicine, Receptor, Cannabinoid, CB1, medicine, Animals, Super-resolution microscopy, Receptor, lcsh:Science, Cells, Cultured, Cytoskeleton, G protein-coupled receptor, Mice, Knockout, Neurons, Multidisciplinary, Chemistry, musculoskeletal, neural, and ocular physiology, Brain, Fluorescence recovery after photobleaching, food and beverages, General Chemistry, Cellular neuroscience, Axons, Molecular Imaging, Cell biology, Mice, Inbred C57BL, 030104 developmental biology, Microscopy, Fluorescence, nervous system, Female, lcsh:Q, lipids (amino acids, peptides, and proteins), Cannabinoid, psychological phenomena and processes, 030217 neurology & neurosurgery, Intracellular, Fluorescence Recovery After Photobleaching
Abstract

G-protein-coupled receptors (GPCRs) play important roles in cellular functions. However, their intracellular organization is largely unknown. Through investigation of the cannabinoid receptor 1 (CB1), we discovered periodically repeating clusters of CB1 hotspots within the axons of neurons. We observed these CB1 hotspots interact with the membrane-associated periodic skeleton (MPS) forming a complex crucial in the regulation of CB1 signaling. Furthermore, we found that CB1 hotspot periodicity increased upon CB1 agonist application, and these activated CB1 displayed less dynamic movement compared to non-activated CB1. Our results suggest that CB1 forms periodic hotspots organized by the MPS as a mechanism to increase signaling efficacy upon activation., Despite the importance of G-protein-coupled receptors in many cellular functions, their intracellular organisation is largely unknown. The authors identified periodically repeating clusters of cannabinoid receptor 1 hotspots within neuronal axons that are dynamically regulated by CB1 agonists.

Published
2020

Catalog

Books, media, physical & digital resources
See catalog results