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Aim: The aim of this study was to evaluate the impact of simulation prebriefing on nursing students' perceptions of overall effectiveness, learning, and self-confidence., Background: Most research highlights debriefing as the most important component influencing learning outcomes; the focus on prebriefing is limited., Method: This quasiexperimental design study compared outcomes among four groups of undergraduate students (n = 119) at two schools of nursing: no prebriefing, prebriefing with learning engagement and orientation activities, prebriefing with orientation activities, and prebriefing with learning engagement activities., Results: Perceptions of overall simulation effectiveness, learning, and self-confidence were significantly higher with prebriefing (p = .000) compared to no prebriefing. No significant distinction (p >.05) was found among the prebriefing activities., Conclusion: Findings from this study support the use of learning engagement and orientation activities during prebriefing in order to enhance overall simulation effectiveness., Competing Interests: The author declares no conflict of interest., (Copyright © 2017 National League for Nursing.)