1. In-Home Coal and Wood Use and Lung Cancer Risk: A Pooled Analysis of the International Lung Cancer Consortium
- Author
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Sander Greenland, John R. McLaughlin, Neonila Szeszenia-Dabrowska, David Zaridze, Nathaniel Rothman, Yuan Chin Amy Lee, Angeline S. Andrew, Paul Brennan, Qing Lan, Adeline Seow, Eleonora Fabianova, Dana Mates, Vladimir Bencko, Paolo Boffetta, Rayjean J. Hung, Lenka Foretova, Peter Rudnai, H. Dean Hosgood, Eric J. Duell, Vladimir Janout, Hal Morgenstern, Jolanta Lissowska, Dean Hosgood, H., Boffetta, P., Greenland, S., Lee, Y.-C.A., Mclaughlin, J., Seow, A., Duell, E.J., Andrew, A.S., Zaridze, D., Szeszenia-Dabrowska, N., Rudnai, P., Lissowska, J., Fabiánová, E., Mates, D., Bencko, V., Foretova, L., Janout, V., Morgenstern, H., Rothman, N., Hung, R.J., Brennan, P., and Lan, Q.
- Subjects
Male ,pooled ,Lung Neoplasms ,Health, Toxicology and Mutagenesis ,Toxicology ,Medical and Health Sciences ,0302 clinical medicine ,In-home coal ,Risk analysis (business) ,Risk Factors ,2.2 Factors relating to the physical environment ,pooled analysi ,030212 general & internal medicine ,Cooking ,Lung ,Cancer ,coal ,Lung Cancer ,Middle Aged ,Wood ,3. Good health ,Pooled analysis ,risk factor ,030220 oncology & carcinogenesis ,Air Pollution, Indoor ,Respiratory ,Female ,International agency ,medicine.medical_specialty ,Heating ,03 medical and health sciences ,Clinical Research ,Environmental health ,Air Pollution ,medicine ,Humans ,Coal ,Indoor ,Risk factor ,Lung cancer ,international lung cancer consortium ,Aged ,business.industry ,Public health ,Prevention ,Research ,Public Health, Environmental and Occupational Health ,International Agencies ,medicine.disease ,lung cancer ,business ,Environmental Sciences - Abstract
Background: Domestic fuel combustion from cooking and heating is an important public health issue because roughly 3 billion people are exposed worldwide. Recently, the International Agency for Research on Cancer classifed indoor emissions from household coal combustion as a human carcinogen (group 1) and from biomass fuel (primarily wood) as a probable human carcinogen (group 2A). oB je c t iv e s: We pooled seven studies from the International Lung Cancer Consortium (5,105 cases and 6,535 controls) to provide further epidemiological evaluation of the association between in-home solid-fuel use, particularly wood, and lung cancer risk. Methods: Using questionnaire data, we classifed subjects as predominant solid-fuel users (e.g., coal, wood) or nonsolid-fuel users (e.g., oil, gas, electricity). Unconditional logistic regression was used to estimate the odds ratios (ORs) and to compute 95% confdence intervals (CIs), adjusting for age, sex, education, smoking status, race/ethnicity, and study center. results: Compared with nonsolid-fuel users, predominant coal users (OR = 1.64; 95% CI, 1.49-1.81), particularly coal users in Asia (OR = 4.93; 95% CI, 3.73-6.52), and predominant wood users in North American and European countries (OR = 1.21; 95% CI, 1.06-1.38) experienced higher risk of lung cancer. Te results were similar in never-smoking women and other subgroups. conclusions: Our results are consistent with previous observations pertaining to in-home coal use and lung cancer risk, support the hypothesis of a carcinogenic potential of in-home wood use, and point to the need for more detailed study of factors afecting these associations.
- Published
- 2010