1. Mutation in West Nile Virus Structural Protein prM during Human Infection.
- Author
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Lustig Y, Lanciotti RS, Hindiyeh M, Keller N, Milo R, Mayan S, and Mendelson E
- Subjects
- Antibodies, Neutralizing blood, Antibodies, Neutralizing immunology, Antibodies, Viral blood, Antibodies, Viral immunology, Enzyme-Linked Immunosorbent Assay, Humans, Immunoglobulin G blood, Immunoglobulin G immunology, Immunoglobulin M blood, Immunoglobulin M immunology, Male, Middle Aged, Phylogeny, RNA, Viral genetics, Viral Load, West Nile Fever diagnosis, West Nile Fever immunology, West Nile virus classification, West Nile virus immunology, West Nile virus isolation & purification, Whole Genome Sequencing, Mutation, Viral Structural Proteins genetics, West Nile Fever virology, West Nile virus genetics
- Abstract
A mutation leading to substitution of a key amino acid in the prM protein of West Nile virus (WNV) occurred during persistent infection of an immunocompetent patient. WNV RNA persisted in the patient's urine and serum in the presence of low-level neutralizing antibodies. This case demonstrates active replication of WNV during persistent infection.
- Published
- 2016
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