1. Enterovirus 68 among children with severe acute respiratory infection, the Philippines.
- Author
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Imamura T, Fuji N, Suzuki A, Tamaki R, Saito M, Aniceto R, Galang H, Sombrero L, Lupisan S, and Oshitani H
- Subjects
- Acute Disease, Adolescent, Child, Child Mortality, Child, Preschool, Enterovirus D, Human classification, Enterovirus D, Human genetics, Enterovirus Infections mortality, Enterovirus Infections physiopathology, Enterovirus Infections virology, Female, Hospitalization statistics & numerical data, Humans, Infant, Infant, Newborn, Male, Molecular Sequence Data, Philippines epidemiology, Phylogeny, Pneumonia, Viral mortality, Pneumonia, Viral physiopathology, Pneumonia, Viral virology, Polymerase Chain Reaction, Sequence Analysis, DNA, Severity of Illness Index, Enterovirus D, Human isolation & purification, Enterovirus Infections epidemiology, Pneumonia, Viral epidemiology
- Abstract
Enterovirus 68 (EV68) is a rare enterovirus associated with respiratory illness that, unlike other enteroviruses, has been identified only from respiratory specimens. We identified EV68 from respiratory specimens of children hospitalized with a diagnosis of severe pneumonia in Leyte, Republic of the Philippines. Twenty-one samples showed high similarity with EV68 by sequencing of 5' nontranslated region; 17 of these samples were confirmed as EV68 by sequencing of viral protein 1 capsid coding region. Most previously reported EV68 cases had been identified as sporadic cases. All 21 patients we identified had severe illness, and 2 died, possibly the first reported fatal cases associated with EV68 infection. Our study suggests that EV68 may be a possible causative agent of severe respiratory illnesses.
- Published
- 2011
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