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Your search keyword '"Li-Hong Ding"' showing total 2 results
Start Over Author "Li-Hong Ding" Publisher national academy of sciences
2 results on '"Li-Hong Ding"'

1. Menin promotes hepatocellular carcinogenesis and epigenetically up-regulates Yap1 transcription

Author

Rong Zheng, Li-Hong Ding, Zijie Feng, Shan-Hua Li, Bin Xu, Zhen-Yu Yin, Shu-Bin Gao, Xiao Lin, Xiao-Min Wang, Sheng Zhang, and Guang-Hui Jin

Subjects
Scaffold protein, Male, Chromatin Immunoprecipitation, Carcinoma, Hepatocellular, Carcinogenesis, Mice, Nude, Cell Cycle Proteins, Kaplan-Meier Estimate, Biology, medicine.disease_cause, Epigenesis, Genetic, Mice, RNA interference, Cell Line, Tumor, Proto-Oncogene Proteins, medicine, Animals, Humans, MEN1, Diethylnitrosamine, Epigenetics, Carbon Tetrachloride, Adaptor Proteins, Signal Transducing, Oligonucleotide Array Sequence Analysis, YAP1, Mice, Knockout, Multidisciplinary, Liver Neoplasms, YAP-Signaling Proteins, Hep G2 Cells, Biological Sciences, Phosphoproteins, Xenograft Model Antitumor Assays, digestive system diseases, Up-Regulation, Mice, Inbred C57BL, Cancer research, H3K4me3, Female, RNA Interference, Chemical and Drug Induced Liver Injury, Chromatin immunoprecipitation
Abstract

Significance Epigenetic changes commonly occur in hepatocellular carcinoma (HCC) and are associated with aberrant gene expression. Most studies have focused on epigenetic gene-silencing events; therefore, the mechanism that promotes gene activation in HCC is not well established. We identify an epigenetic activation mechanism whereby menin promotes Yes-associated protein (Yap1) transcription, which is associated with a poor prognosis for HCC patients. Substantial overexpression of the menin–mixed-lineage leukemia complex is associated with increased histone 3 lysine 4 trimethylation at certain loci of the tumor promoter in HCC. Heterozygous ablation of multiple endocrine neoplasia type 1 ( Men1) in mice reduces diethylnitrosamine-induced development of HCC. Our findings reveal that menin plays an important epigenetic role in up-regulating Yap1 transcription, leading to liver tumorigenesis.

Published
2013

2. Menin promotes hepatocellular carcinogenesis and epigenetically up-regulates Yap1 transcription.

Author

Bin Xu, Shan-Hua Li, Rong Zheng, Shu-Bin Gao, Li-Hong Ding, Zhen-Yu Yin, Xiao Lin, Zi-Jie Feng, Sheng Zhang, Xiao-Min Wang, and Guang-Hui Jin

Subjects
MENIN, LIVER cancer, CARCINOGENESIS, CERVICAL intraepithelial neoplasia, CARCINOGENS -- Risk factors, LABORATORY rats
Abstract

Menin is a scaffold protein encoded by the multiple endocrine neoplasia type 1 (MEN1) gene in humans, and it interacts with a variety of transcriptional proteins to control active or repressive cellular processes. Here, we show that heterozygous ablation of Men1 in female mice reduces chemical carcinogen-induced liver carcinogenesis and represses the activation of the inflammation pathway. Using ChIP-on-chip screens and ChIP assays, we find that menin occupancy frequently coincides with H3K4me3 at the promoter of many liver cancer-related genes, such as Yes-associated protein (Yap1). Increased menin and Yap1 expression in human hepatocellular carcinoma specimens was associated with poor prognosis. Our findings reveal that menin plays an important epigenetic role in promoting liver tumorigenesis, and support the notion that H3K4me3, which is regulated by the menin-mixedlineage leukemia complex, is a potential therapeutic target in hepatocellular carcinoma. [ABSTRACT FROM AUTHOR]

Published
2013
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