1. Proliferation and phenotype regulation in the subventricular zone during experimental allergic encephalomyelitis: in vivo evidence of a role for nerve growth factor.
- Author
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Calzà L, Giardino L, Pozza M, Bettelli C, Micera A, and Aloe L
- Subjects
- Animals, Autoantigens, Biomarkers, Cell Differentiation, Cell Division, Cell Movement, Corpus Callosum cytology, Female, Nuclear Proteins isolation & purification, Olfactory Bulb metabolism, Phenotype, Proteasome Endopeptidase Complex, Proto-Oncogene Proteins biosynthesis, Rats, Rats, Inbred Lew, Receptor Protein-Tyrosine Kinases biosynthesis, Receptor, Nerve Growth Factor, Receptor, trkA, Receptors, Nerve Growth Factor biosynthesis, Receptors, Nerve Growth Factor isolation & purification, Cerebral Ventricles cytology, Cerebral Ventricles metabolism, Encephalomyelitis, Autoimmune, Experimental metabolism, Nerve Growth Factors metabolism
- Abstract
Proliferating cells in the subventricular zone (SVZ) of adult rat brain could provide a source of cells for repair attempts during degenerative diseases. However, very few reports dealt with the spontaneous regulation of this cell population during experimental conditions. In this paper, we describe an increase in the proliferation activity in the SVZ during experimental allergic encephalomyelitis, a demyelinating disease widely used as an experimental model for human multiple sclerosis. Moreover, p75(LNGFR)-immunoreactive elements in the SVZ were larger in experimental allergic encephalomyelitis compared with control groups, and they also showed multiple and branched elongations. Finally, a selective uptake of 125I-nerve growth factor was observed in the SVZ in neonatal rats, and positive elements migrated in the corpus callosum within a few days. These data indicate that cell populations in the SVZ are regulated during inflammatory conditions and degenerative diseases involving oligodendrocytes and neurotrophins, including nerve growth factor, could participate in these phenomena.
- Published
- 1998
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