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A White Paper on Building a Scientific Roadmap to a Carbon-Negative Agricultural System was drafted by a scientific working group of the U.S. Farmers & Ranchers in Action (USFRA). At the request of the USFRA and with support from the Foundation for Food and Agricultural Research, the National Academies of Sciences, Engineering, and Medicine appointed a six-person committee to review the draft white paper by examining its clarity of key messages, effectiveness of organization, and scientific rigor.

This volume contains working papers on astronomy and astrophysics prepared by 15 non-National Research Council panels in areas ranging from radio astronomy to the status of the profession.

Over the last two decades, colleges and universities in the United States have significantly increased the formal ethics instruction they provide in science and engineering. Today, science and engineering programs socialize students into the values of scientists and engineers as well as their obligations in the conduct of scientific research and in the practice of engineering. Practical Guidance on Science and Engineering Ethics Education for Instructors and Administrators is the summary of a workshop convened in December 2012 to consider best practices for ethics education programs in science and engineering. The workshop focused on four key areas: goals and objectives for ethics instruction, instructional assessment, institutional and research cultures, and development of guidance checklists for instructors and administrators. Leading experts summarized and presented papers on current research knowledge in these areas. This report presents the edited papers and a summary of the discussions at the workshop.

Sociality, Hierarchy, Health: Comparative Biodemography is a collection of papers that examine cross-species comparisons of social environments with a focus on social behaviors along with social hierarchies and connections, to examine their effects on health, longevity, and life histories. This report covers a broad spectrum of nonhuman animals, exploring a variety of measures of position in social hierarchies and social networks, drawing links among these factors to health outcomes and trajectories, and comparing them to those in humans. Sociality, Hierarchy, Health revisits both the theoretical underpinnings of biodemography and the empirical findings that have emerged over the past two decades.

Those involved in the drug development process face challenges of efficiency and overall sustainability due in part to high research costs, lengthy development timelines, and late-stage drug failures. Novel clinical trial designs that enroll participants based on their genetics represent a potentially disruptive change that could improve patient outcomes, reduce costs associated with drug development, and further realize the goals of precision medicine. On March 8, 2017, the Forum on Drug Discovery, Development, and Translation and the Roundtable on Genomics and Precision Health of the National Academies of Sciences, Engineering, and Medicine hosted the workshop Enabling Precision Medicine: The Role of Genetics in Clinical Drug Development. Participants examined successes, challenges, and possible best practices for effectively using genetic information in the design and implementation of clinical trials to support the development of precision medicines, including exploring the potential advantages and disadvantages of such trials across a variety of disease areas. This publication summarizes the presentations and discussions from the workshop.

Engineering professional societies in the United States are engaged in a wide range of activities involving undergraduate education. However, these activities generally are not coordinated and have not been assessed in such a way that information about their procedures and outcomes can be shared. Nor have they been assessed to determine whether they are optimally configured to mesh with corresponding initiatives undertaken by industry and academia. Engineering societies work largely independently on undergraduate education, leaving open the question of how much more effective their efforts could be if they worked more collaboratively—with each other as well as with academia and industry. To explore the potential for enhancing societies'role at the undergraduate level, the National Academy of Engineering held a workshop on the engagement of engineering societies in undergraduate engineering education. This publication summarizes the presentations and discussions from the workshop.

As of 2017, the emergence and spread of antimicrobial resistance continues unabated around the world, leaving devastating health and economic outcomes in its wake. Those consequences will multiply if collaborative global action is not taken to address the spread of resistance. Major drivers of antimicrobial resistance in humans have been accelerated by inappropriate antimicrobial prescribing in health care practices; the inappropriate use of antimicrobials in livestock; and the promulgation of antibiotic resistance genes in the environment. To explore the issue of antimicrobial resistance, the Forum of Microbial Threats planned a public workshop. Participants explored issues of antimicrobial resistance through the lens of One Health, which is a collaborative approach of multiple disciplines - working locally, nationally, and globally - for strengthening systems to counter infectious diseases and related issues that threaten human, animal, and environmental health, with an end point of improving global health and achieving gains in development. They also discussed immediate and short-term actions and research needs that will have the greatest effect on reducing antimicrobial resistance, while taking into account the complexities of bridging different sectors and disciplines to address this global threat. This publication summarizes the presentations and discussions from the workshop.

The U.S. Air Force has experienced many acquisition program failures - cost overruns, schedule delays, system performance problems, and sustainability concerns - over program lifetimes. A key contributing factor is the lack of sufficient technical knowledge within the Air Force concerning the systems being acquired to ensure success. To examine this issue, the Assistant Secretary of the Air Force for Acquisition requested that the Air Force Studies Board of the National Research Council undertake a workshop to identify the essential elements of the technical baseline - data and information to establish, trade-off, verify, change, accept, and sustain functional capabilities, design characteristics, affordability, schedule, and quantified performance parameters at the chosen level of the system hierarchy - that would benefit from realignment under Air Force or government ownership, and the value to the Air Force of regaining ownership under its design capture process of the future. Over the course of three workshops from November 2014 through January 2015, presenters and participants identified the barriers that must be addressed for the Air Force to regain technical baseline control to include workforce, policy and process, funding, culture, contracts, and other factors and provided a terms of reference for a possible follow-on study to explore the issues and make recommendations required to implement and institutionalize the technical baseline concept. Owning the Technical Baseline for Acquisition Programs in the U.S. Air Force summarizes the presentations and discussion of the three workshops.

Beginning in late 2004, the IOM began a project to take a new look at disability in America. It will review developments and progress since the publication of the 1991 and 1997 Institute reports. For technical contracting reasons, the new project was split into two phases. During the limited first phase, a committee appointed by IOM planned and convened a 1-day workshop to examine a subset of topics as background for the second phase of project. As was agreed upon with the sponsor of the workshop, the Centers for Disease Control and Prevention (CDC), the topics were: methodological and policy issues related to the conceptualization, definition, measurement, and monitoring of disability and health over time; trends in the amount, types, and causes of disability; disability across the age spectrum and in the context of normal aging; and secondary health conditions. The phase-one workshop was held in Washington, D.C. on August 1, 2005. Its participants included researchers, clinicians, social service professionals, policy experts, and consumer representatives and advocates. The meeting agenda and list of participants are included in Appendix A. Workshop on Disability in America: A New Look- Summary and Background Papers summarizes the workshop presentations and discussions. The background papers prepared for the workshop are included in Appendixes B through O. Some papers were submitted and circulated in advance of the meeting, whereas others were first presented at the meeting. The analyses, definitions, and views presented in the papers are those of the paper authors and are not necessarily those of the IOM committee. Likewise, the discussion summary is limited to the views of the workshop participants.

Potential health effects from chemicals that disrupt endocrine function pose an environmental health concern because of their ability to interfere with normal hormone function in human and wildlife populations. The endocrine system regulates biological processes throughout the body and is sensitive to small changes in hormone concentrations. Endocrine-disruptor research has focused primarily on chemicals that affect three hormone pathways that play important roles in reproduction and development - the estrogen, androgen, and thyroid hormone pathways. Some of this research has identified dose-response relationships that have nonmonotonic curves. Nonmonotonic dose-response curves (NMDRs) are of concern because they do not follow the usual assumption made in toxicology that as dose decreases the response also decreases. The existence of NMDRs has been a controversial topic for decades, and there has been considerable debate about their implications for how chemicals are tested and for how risks from such chemicals are assessed. Toxicity tests are designed to identify hazards and to characterize dose-response relationships, so tests are aimed at finding a (high) dose that elicits a response, and dose-response is explored by testing lower doses spaced to identify statistically a no- or lowest-observed-adverse-effect level. The concern for NMDRs is that such studies, as currently designed, might not detect the inflection of the dose-response curve if only a few doses are tested or if the change in inflection occurs below the range of doses tested. Another concern is that some NMDRs are found for biological effects that are not usually evaluated in toxicity tests. If current testing strategies are inadequate to account for NMDRs, changes to risk assessment practices might be necessary. To help address these issues, the U.S. Environmental Protection Agency (EPA) developed a draft State-of-the-Science Evaluation: Nonmonotonic Dose Responses as they Apply to Estrogen, Androgen, and Thyroid Pathways and EPA Testing and Assessment Procedures. EPA asked the National Research Council to conduct an independent review of this evaluation to ensure that it is scientifically sound and of high quality. Review of Environmental Protection Agency's State-of-the-Science Evaluation of Nonmonotonic Dose-Response as they Apply to Endocrine Disrupters evaluates whether EPA's evaluation presents a scientifically sound and high-quality analysis of the literature on NMDRs. This report reviews how well the EPA evaluation described how the assessment was performed, whether consistent methods and criteria were applied in the analysis of different evidence streams, and whether appropriate methods were applied to evaluating the evidence. The report makes recommendations to improve EPA's process and strengthen the evaluation.

Engineers and ethicists participated in a workshop to discuss the responsible development of new technologies. Presenters examined four areas of engineering—sustainability, nanotechnology, neurotechnology, and energy—in terms of the ethical issues they present to engineers in particular and society as a whole. Approaches to ethical issues include: analyzing the factual, conceptual, application, and moral aspects of an issue; evaluating the risks and responsibilities of a particular course of action; and using theories of ethics or codes of ethics developed by engineering societies as a basis for decision making. Ethics can be built into the education of engineering students and professionals, either as an aspect of courses already being taught or as a component of engineering projects to be examined along with research findings. Engineering practice workshops can also be effective, particularly when they include discussions with experienced engineers. This volume includes papers on all of these topics by experts in many fields. The consensus among workshop participants is that material on ethics should be an ongoing part of engineering education and engineering practice.

The Panel on Statistical Methods for Testing and Evaluating Defense Systems had a broad mandate—to examine the use of statistics in conjunction with defense testing. This involved examining methods for software testing, reliability test planning and estimation, validation of modeling and simulation, and use of modem techniques for experimental design. Given the breadth of these areas, including the great variety of applications and special issues that arise, making a contribution in each of these areas required that the Panel's work and recommendations be at a relatively general level. However, a variety of more specific research issues were either brought to the Panel's attention by members of the test and acquisition community, e.g., what was referred to as Dubin's challenge (addressed in the Panel's interim report), or were identified by members of the panel. In many of these cases the panel thought that a more in-depth analysis or a more detailed application of suggestions or recommendations made by the Panel would either be useful as input to its deliberations or could be used to help communicate more individual views of members of the Panel to the defense test community. This resulted in several research efforts. Given various criteria, especially immediate relevance to the test and acquisition community, the Panel has decided to make available three technical or background papers, each authored by a Panel member jointly with a colleague. These papers are individual contributions and are not a consensus product of the Panel; however, the Panel has drawn from these papers in preparation of its final report: Statistics, Testing, and Defense Acquisition. The Panel has found each of these papers to be extremely useful and they are strongly recommended to readers of the Panel's final report.

This companion to Volume I presents individually authored papers covering the history, economics, and sociology of women's work and the computer revolution. Topics include the implications for equal employment opportunity in light of new technologies; a case study of the insurance industry and of women in computer-related occupations; a study of temporary, part-time, and at-home employment; and education and retraining opportunities.

Estimated costs associated with lost days and compensation claims related to musculoskeletal disorders—including back pains and repetitive motion injuries—range from $13 billion to $20 billion annually. This is a serious national problem that has spurred considerable debate about the causal links between such disorders and risk factors in the workplace. This book presents a preliminary assessment of what is known about the relationship between musculoskeletal disorders and what may cause them. It includes papers and a workshop summary of findings from orthopedic surgery, public health, occupational medicine, epidemiology, risk analysis, ergonomics, and human factors. Topics covered include the biological responses of tissues to stress, the biomechanics of work stressors, the epidemiology of physical work factors, and the contributions of individual, recreational, and social factors to such disorders. The book also considers the relative success of various workplace interventions for prevention and rehabilitation.

Drawing on the historical changes in five areas—the jobs of telephone operators, workers in the printing and publishing industries, information and data processors, retail clerks, and nurses—this volume offers a comprehensive examination of how microelectronics and telecommunications have affected women's work and their working environments and looks ahead to what can be expected for women workers in the next decade. It also offers perspectives on how workers can more easily adapt to the changing workplace and addresses the controversial topic of job insecurity as a result of an influx of advanced electronic systems.

In the summer of 2002, the Office of Naval Research asked the Committee on Human Factors to hold a workshop on dynamic social network and analysis. The primary purpose of the workshop was to bring together scientists who represent a diversity of views and approaches to share their insights, commentary, and critiques on the developing body of social network analysis research and application. The secondary purpose was to provide sound models and applications for current problems of national importance, with a particular focus on national security. This workshop is one of several activities undertaken by the National Research Council that bears on the contributions of various scientific disciplines to understanding and defending against terrorism. The presentations were grouped in four sessions — Social Network Theory Perspectives, Dynamic Social Networks, Metrics and Models, and Networked Worlds — each of which concluded with a discussant-led roundtable discussion among the presenters and workshop attendees on the themes and issues raised in the session.

Intelligence analysts conduct these analyses every day, using decades of propriety tradecraft techniques and an arsenal of clandestine information gathering sources, but the resources available are not unlimited. Open source public opinion tools can provide timely and relatively inexpensive methods of understanding fast-moving conditions, acting as a force multiplier to help policymakers have a truly all-source understanding of complex events. By providing analysts with the best practices in survey methodology and nonsurvey methods for gathering data on public opinion, they will be armed with a clearer sense of important shifts in attitudes, elections, and unrest. In order to provide guidance to analysts on strategies for assessing public opinion, representatives from the intelligence community approached the National Academies of Sciences, Engineering, and Medicine to request preparation of a framework on Measuring and Analyzing Public Opinion. This analytic framework includes three layers of information. Layer 1 comprises four authored papers that review literature from various disciplines containing overview information as well as how the topic/situation of interest can enable better analysis across different situational constraints. Layer 2 is a distilled layer of information in the form of an authored summary of the four Layer 1 papers, both summarizing and describing key points. Finally, Layer 3 provides an even further distillation of the key concepts, in a one-page visual graphic, that displays key drivers from the work in Layers 1 and 2 to help the intended audience apply knowledge to the situation of interest.

To explore how mobile technology can be employed to enhance the lives of older adults, the Board on Behavioral, Cognitive, and Sensory Sciences of the National Academies of Sciences, Engineering, and Medicine commissioned 6 papers, which were presented at a workshop held on December 11 and 12, 2019. These papers review research on mobile technologies and aging, and highlight promising avenues for further research.

Health literacy, cultural competence, and language access services are distinct but inextricably linked concepts for delivering equitable care to all members of the increasingly diverse population of the United States. These concepts are linked, but they developed via different paths, and each has its own unique focus with regard to enabling every individual to obtain the ability to process and understand basic health information and services needed to make appropriate health care decisions. Fragmentation of these disciplines has impeded implementation of relevant measures for quality improvement and accountability. To foster an integrated approach to health literacy, cultural competency, and language access services, the Roundtable on Health Literacy initiated a project with three components: a commissioned paper to propose a framework for integrating measurements of health literacy, cultural competency, and language access; a workshop to review and discuss the framework; and a second commissioned paper that will provide a roadmap for integrating health literacy, cultural competency, and language access services as well as a revised measurement framework. Held on May 4, 2017, the workshop explored the quality performance measures for integration of health literacy, cultural competence, and language access services. This publication summarizes the presentations and discussions from the workshop.

Health literacy is the degree to which individuals can obtain, process, and understand the basic health information and services they need to make appropriate health decisions. Nearly half of all American adults - 90 million people - have inadequate health literacy to navigate the health care system. Implications of Health Literacy for Public Health is the summary of a workshop convened by the Institute of Medicine Roundtable on Health Literacy in November 2013 that focused on the implications of health literacy for the mission and essential services of public health. The workshop featured the presentation of a commissioned paper on health literacy activities under way in public health organizations. Other presentations examined the implications of health literacy for the mission and essential services of public health, for example, community health and safety, disease prevention, disaster management, or health communication. This report includes the commissioned paper and summaries of the workshop presentations.

Although health literacy is commonly defined as an individual trait, it does not depend on the skills of individuals alone. Health literacy is the product of the interaction between individuals'capacities and the health literacy-related demands and complexities of the health care system. Specifically, the ability to understand, evaluate, and use numbers is important to making informed health care choices. Health Literacy and Numeracy is the summary of a workshop convened by The Institute of Medicine Roundtable on Health Literacy in July 2013 to discuss topics related to numeracy, including the effects of ill health on cognitive capacity, issues with communication of health information to the public, and communicating numeric information for decision making. This report includes a paper commissioned by the Roundtable,'Numeracy and the Affordable Care Act: Opportunities and Challenges,'that discusses research findings about people's numeracy skill levels; the kinds of numeracy skills that are needed to select a health plan, choose treatments, and understand medication instructions; and how providers should communicate with those with low numeracy skills. The paper was featured in the workshop and served as the basis of discussion.

The practice of engineering is continually changing. Engineers today must be able not only to thrive in an environment of rapid technological change and globalization, but also to work on interdisciplinary teams. Cutting-edge research is being done at the intersections of engineering disciplines, and successful researchers and practitioners must be aware of developments and challenges in areas that may not be familiar to them. At the U.S. Frontiers of Engineer Symposium, engineers have the opportunity to learn from their peers about pioneering work being done in many areas of engineering. Frontiers of Engineering 2011: Reports on Leading-Edge Engineering from the 2011 Symposium highlights the papers presented at the event. This book covers four general topics from the 2011 symposium: additive manufacturing, semantic processing, engineering sustainable buildings, and neuro-prosthetics. The papers from these presentations provide an overview of the challenges and opportunities of these fields of inquiry, and communicate the excitement of discovery.

The population of Asia is growing both larger and older. Demographically the most important continent on the world, Asia's population, currently estimated to be 4.2 billion, is expected to increase to about 5.9 billion by 2050. Rapid declines in fertility, together with rising life expectancy, are altering the age structure of the population so that in 2050, for the first time in history, there will be roughly as many people in Asia over the age of 65 as under the age of 15. It is against this backdrop that the Division of Behavioral and Social Research at the U.S. National Institute on Aging (NIA) asked the National Research Council (NRC), through the Committee on Population, to undertake a project on advancing behavioral and social research on aging in Asia. Aging in Asia: Findings from New and Emerging Data Initiatives is a peer-reviewed collection of papers from China, India, Indonesia, Japan, and Thailand that were presented at two conferences organized in conjunction with the Chinese Academy of Sciences, Indian National Science Academy, Indonesian Academy of Sciences, and Science Council of Japan; the first conference was hosted by the Chinese Academy of Social Sciences in Beijing, and the second conference was hosted by the Indian National Science Academy in New Delhi. The papers in the volume highlight the contributions from new and emerging data initiatives in the region and cover subject areas such as economic growth, labor markets, and consumption; family roles and responsibilities; and labor markets and consumption.