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Objective: To identify the impact of MUC5B polymorphisms on dental caries., Methods: A case-control study was performed with patients recruited at Pontifícia Universidade Católica do Paraná. These individuals were aged 12 years old or more. Dental caries was diagnosed using the International Caries Detection and Assessment System, and the effects of socioeconomic, dietary, and hygiene factors on dental caries were investigated. Furthermore, buccal cells were collected, and their DNA was extracted and amplified using PCR. Uni-, bi-, and multivariate analyses were performed., Results: Two hundred patients were recruited, 100 were assigned to the case group and 100 to the control group. In the bivariate analysis, the following variables showed significant results: ethnicity (p = .008), biofilm (p < .001), and gingivitis (p < .001). The MUC5B gene affected dental caries with the markers rs2735733 (p < .001), rs2249073 (p < .001), and rs2857476 (p < .001). In the multivariate analysis, the biofilm variable remained significant (p = .026), as did the following markers from the MUC5B gene: rs2735733 (p = .019), rs2249073 (p < .025), and rs2857476 (p < .005)., Conclusion: Genetic variations in the MUC5B gene can influence dental caries., (© 2017 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd. All rights reserved.)

The aims of this study were to assess the epidemiology of traumatic dental injuries (TDI) to primary teeth in infants and toddlers between 1 and 3 years of age and investigate whether TDI was related to biological and social factors. A representative sample of infants and toddlers in the city of Belo Horizonte, Minas Gerais, Brazil (n = 519) was examined during a vaccination campaign. The evaluation of clinical signs of previous dental trauma was performed by nine previously calibrated examiners (intra-examiner Kappa = 0.95%; inter-examiner Kappa = 0.88%). Data were analysed through descriptive analysis, the chi-squared test (P < 0.050) and logistic regression. The prevalence of dental trauma was 41.6%. Among the 519 children examined, 193 (37.2%) had enamel fractures, 30 (5.7%) had enamel-dentin fractures and only three (0.6%) had enamel-dentin fractures involving the pulp. Dental care had been performed within the first 24 h in 4.1% of the sample and after 36 h in 0.8% of the sample. There was no statistically significant difference between genders. The most reported aetiologies were falls (28.8%) and collisions (6.8%). There were no statistically significant associations between the prevalence of dental trauma and non-nutritive sucking habits, dental caries or lip incompetence (P > 0.050). Children of mothers with low levels of schooling (0-6 years of study) had a greater prevalence of TDI (P = 0.001). The results of the logistic regression also demonstrated a significant association between dental injury and the Social Vulnerability Index (P = 0.045). Children from families with high social vulnerability (worse living conditions) had a 1.51 (95% confidence interval 1.0-2.2) greater chance of exhibiting TDI. These results can help guide the implementation of health promotion policies.

The purpose of this study was to build epidemiological indicators on the experience of dental trauma in 12-year-old schoolchildren in the city of Curitiba, Brazil, exploring its geographical and population distributions. A geographic information system (GIS) was used, built by means of ArcView GIS 3.2 software and geographical databases of streets and districts defined within the boundaries of the city of Curitiba, provided by Curitiba's Institute of Research and Public Planning (IPPUC). The database used in the study was compiled based on an epidemiological survey undertaken in 1998 on a sample of 2126 schoolchildren 12 years old, residing in outlying urban suburbs distributed over 29 micro-areas in the city of Curitiba. The cases selected for this study were those with a history of dental trauma, thereby comprising a subsample of 327 schoolchildren. The spatial location of the schoolchildren's homes enabled the events to be visualized on a cartographic basis. The variables of gender, aetiology of the trauma and areas of substandard living conditions were included in the analysis and construction of thematic maps, thus making possible a descriptive analysis of the spatial distribution of dental trauma in the city. Intra-urban differentials were identified in the prevalence of dental trauma in 12-year-old schoolchildren in Curitiba. A greater concentration of occurrences was observed in the eastern region of the city, especially in areas of substandard living conditions. It was possible to conclude that socio-environmental and geophysical factors are associated with the determination of dental trauma in the city of Curitiba, pointing to the need for the development of public policies especially aimed at areas and populations at greater risk.