1. Direct Modification of Microcrystalline Cellulose with Ethylenediamine for Use as Adsorbent for Removal Amitriptyline Drug from Environment
- Author
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Thiago H. C. Marques, Mateus S. Silva, Alan Ícaro Sousa Morais, Régis C. Leal, Josy Anteveli Osajima, Edson Cavalcanti da Silva Filho, Hernane da Silva Barud, Andréia Bagliotti Meneguin, and Roosevelt D.S. Bezerra
- Subjects
Models, Molecular ,Magnetic Resonance Spectroscopy ,modified cellulose ,amitriptyline ,adsorption ,Amitriptyline ,Inorganic chemistry ,Pharmaceutical Science ,Ethylenediamine ,02 engineering and technology ,010402 general chemistry ,01 natural sciences ,Article ,Analytical Chemistry ,lcsh:QD241-441 ,chemistry.chemical_compound ,Differential scanning calorimetry ,Adsorption ,lcsh:Organic chemistry ,X-Ray Diffraction ,Drug Discovery ,Physical and Theoretical Chemistry ,Fourier transform infrared spectroscopy ,Cellulose ,Aqueous solution ,Molecular Structure ,Organic Chemistry ,Temperature ,Hydrogen-Ion Concentration ,Ethylenediamines ,021001 nanoscience & nanotechnology ,0104 chemical sciences ,Microcrystalline cellulose ,Thermogravimetry ,Kinetics ,chemistry ,Chemistry (miscellaneous) ,Thermodynamics ,Molecular Medicine ,0210 nano-technology ,Water Pollutants, Chemical - Abstract
Cellulose derivatives have been widely used as adsorbents for the removal of micropollutants such as drugs, dyes, and metals, due to their abundance, low cost and non-contaminating nature. In this context, several studies have been performed searching for new adsorbents (cellulose derivatives) efficient at contaminant removal from aqueous solutions. Thus, a new adsorbent was synthesized by chemical modification of cellulose with ethylenediamine in the absence of solvent and applied to the adsorption of amitriptyline (AMI) in aqueous solution. The modification reaction was confirmed by X-ray Diffraction (XRD), elemental analysis, Fourier Transform Infrared Spectroscopy (FTIR), Thermogravimetry/Differential Scanning Calorimeter (TG/DSC), solid state Nuclear Magnetic Resonance of 1H and 13C (1H-NMR and 13C-NMR). Moreover, the effectiveness of reaction was confirmed by computational calculations using Density Functional Theory (DFT) at level B3LYP/6-31G(d). This adsorption process was influenced by pH, time, concentration, temperature and did not show significant changes due to the ionic strength variation. Through these experiments, it was observed that the maximum adsorption capacity of AMI by CN polymer at 298 K, 300 min, and pH 7 was 87.66 ± 0.60 mg·g−1.
- Published
- 2017
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