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The reduction of the cerebral glucose metabolism is closely related to the activation of the NOD-like receptor protein 3 (NLRP3) inflammasome in Alzheimer’s disease (AD); however, its underlying mechanism remains unclear. In this paper, 18F-flurodeoxyglucose positron emission tomography was used to trace cerebral glucose metabolism in vivo, along with Western blotting and immunofluorescence assays to examine the expression and distribution of associated proteins. Glucose and insulin tolerance tests were carried out to detect insulin resistance, and the Morris water maze was used to test the spatial learning and memory ability of the mice. The results show increased NLRP3 inflammasome activation, elevated insulin resistance, and decreased glucose metabolism in 3×Tg-AD mice. Inhibiting NLRP3 inflammasome activation using CY-09, a specific inhibitor for NLRP3, may restore cerebral glucose metabolism by increasing the expression and distribution of glucose transporters and enzymes and attenuating insulin resistance in AD mice. Moreover, CY-09 helps to improve AD pathology and relieve cognitive impairment in these mice. Although CY-09 has no significant effect on ferroptosis, it can effectively reduce fatty acid synthesis and lipid peroxidation. These findings provide new evidence for NLRP3 inflammasome as a therapeutic target for AD, suggesting that CY-09 may be a potential drug for the treatment of this disease.

In the context of the commitment to peak carbon emissions by 2030, specific sectors in China should take responsibility to change their energy consumption patterns. In China and across the globe, the construction sector is a major source of carbon dioxide emissions, as well as an indicator of economic growth and structural transformation. In this study, we examine panel data for 30 provinces or regions from 2008 to 2019 to dissect which macro-factors contribute to growth in carbon emissions, and which will lead to carbon emission reductions. Derived by the entropy method, the Green Finance Index is a comprehensive environmental regulation index related to reduction in emissions in each province. It presents an N shape for construction emissions, and provinces are currently striving to cross the first inflection point, which will help to curb emissions. Judging from the combined effects of this and other structural factors, the Green Finance Index can promote the decarbonization of production by playing the role of guiding and screening capital allocation. Population expansion, income levels, and financial development initially stimulate demand for construction, but their effects eventually level off. This paper can serve as a reference for developing countries that are experiencing industrialization and urbanization processes and handling gas discharge pressure at the same time.