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Magnetic nanoparticles enhanced microwave imaging relies on the capability of modulating the response of such nanocomponents at microwaves by means of a (low frequency) polarizing magnetic field. In medical imaging, this capability allows for the detection and imaging of tumors loaded with nanoparticles. As the useful signal is the one which arises from nanoparticles, it is crucial to remove sources of undesired disturbance to enable the diagnosis of early-stage tumors. In particular, spurious signals arise from instrumental drift, as well as from the unavoidable interaction between the polarizing field and the imaging system. In this paper, we experimentally assess and characterize such spurious effects in order to set the optimal working conditions for magnetic nanoparticles enhanced microwave imaging of cancer. To this end, simple test devices, which include all components typically comprised in a microwave imaging system, have been realized and exploited. The experiment’s results allow us to derive design formulas and guidelines useful for limiting the impact of unwanted magnetic effects, as well as that relative to the instrumental drift on the signal generated by the magnetic nanoparticles-loaded tumor.