1. Behavioral Health Diagnoses in Youth with Differences of Sex Development or Congenital Adrenal Hyperplasia Compared with Controls: A PEDSnet Study.
- Author
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Sewell R, Buchanan CL, Davis S, Christakis DA, Dempsey A, Furniss A, Kazak AE, Kerlek AJ, Magnusen B, Pajor NM, Pyle L, Pyle LC, Razzaghi H, Schwartz BI, Vogiatzi MG, and Nokoff NJ
- Subjects
- Adolescent, Adrenal Hyperplasia, Congenital complications, Case-Control Studies, Child, Child Behavior Disorders diagnosis, Child Behavior Disorders epidemiology, Child Behavior Disorders etiology, Child, Preschool, Databases, Factual, Developmental Disabilities diagnosis, Developmental Disabilities epidemiology, Developmental Disabilities etiology, Disorders of Sex Development complications, Electronic Health Records, Female, Humans, Infant, Infant, Newborn, Logistic Models, Male, Mental Disorders diagnosis, Mental Disorders epidemiology, Neurodevelopmental Disorders diagnosis, Neurodevelopmental Disorders epidemiology, Neurodevelopmental Disorders etiology, Odds Ratio, Propensity Score, Risk Factors, Adrenal Hyperplasia, Congenital psychology, Disorders of Sex Development psychology, Mental Disorders etiology
- Abstract
Objective: To evaluate the odds of a behavioral health diagnosis among youth with differences of sex development (DSD) or congenital adrenal hyperplasia (CAH) compared with matched controls in the PEDSnet database., Study Design: All youth with a diagnosis of DSD (n = 1216) or CAH (n = 1647) and at least 1 outpatient encounter were extracted from the PEDSnet database and propensity-score matched on 8 variables (1:4) with controls (n = 4864 and 6588, respectively) using multivariable logistic regression. The likelihood of having behavioral health diagnoses was examined using generalized estimating equations., Results: Youth with DSD had higher odds of a behavioral health diagnosis (OR, 1.7; 95% CI, 1.4-2.1; P < .0001) and neurodevelopmental diagnosis (OR, 1.7; 95% CI, 1.4, 2.0; P < .0001) compared with matched controls. Youth with CAH did not have an increased odds of a behavioral health diagnosis (OR, 1.0; 95% CI, 0.9, 1.1; P = .9) compared with matched controls but did have higher odds of developmental delay (OR, 1.8; 95% CI, 1.4, 2.4; P < .0001)., Conclusions: Youth with DSD diagnosis have higher odds of a behavioral health or neurodevelopmental diagnosis compared with matched controls. Youth with CAH have higher odds of developmental delay, highlighting the need for screening in both groups., (Copyright © 2021 Elsevier Inc. All rights reserved.)
- Published
- 2021
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