1. Airway smooth muscle pathophysiology in asthma.
- Author
-
Camoretti-Mercado B and Lockey RF
- Subjects
- Airway Remodeling genetics, Airway Remodeling immunology, Animals, Biomarkers, Bronchoconstriction genetics, Bronchoconstriction immunology, Gene Expression Regulation, Humans, Muscle, Smooth physiopathology, Myocytes, Smooth Muscle metabolism, Asthma etiology, Asthma metabolism, Disease Susceptibility, Muscle, Smooth metabolism
- Abstract
The airway smooth muscle (ASM) cell plays a central role in the pathogenesis of asthma and constitutes an important target for treatment. These cells control muscle tone and thus regulate the opening of the airway lumen and air passage. Evidence indicates that ASM cells participate in the airway hyperresponsiveness as well as the inflammatory and remodeling processes observed in asthmatic subjects. Therapeutic approaches require a comprehensive understanding of the structure and function of the ASM in both the normal and disease states. This review updates current knowledge about ASM and its effects on airway narrowing, remodeling, and inflammation in asthma., (Copyright © 2021 American Academy of Allergy, Asthma & Immunology. Published by Elsevier Inc. All rights reserved.)
- Published
- 2021
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