1. Activity Measurement of 44Sc and Calibration of Activity Measurement Instruments on Production Sites and Clinics
- Author
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Frederic Juget, Teresa Durán, Youcef Nedjadi, Zeynep Talip, Pascal V. Grundler, Chiara Favaretto, Pierluigi Casolaro, Gaia Dellepiane, Saverio Braccini, Claude Bailat, and Nicholas P. van der Meulen
- Subjects
positron emission tomography ,530 Physics ,Organic Chemistry ,precise activity measurement ,Pharmaceutical Science ,Analytical Chemistry ,dose calibrator ,Chemistry (miscellaneous) ,precise instruments calibration ,Drug Discovery ,Molecular Medicine ,Sc-44 production ,medical cyclotron ,γ-ray spectrometry ,Physical and Theoretical Chemistry - Abstract
44Sc is a promising radionuclide for positron emission tomography (PET) in nuclear medicine. As a part of the implementation of a production site for 44Sc, precise knowledge of the activity of the product is necessary. At the Paul Scherrer Institute (PSI) and the University of Bern (UniBE), 44Sc is produced by enriched 44CaO-target irradiation with a cyclotron. The two sites use different techniques for activity measurement, namely a dose calibrator at the PSI and a gamma-ray spectrometry system at UniBE and PSI. In this work, the 44Sc was produced at the PSI, and samples of the product were prepared in dedicated containers for onsite measurements at PSI, UniBE, and the Institute of Radiation Physics (IRA) in Lausanne for precise activity measurement using primary techniques and for the calibration of the reference ionization chambers. An accuracy of 1% was obtained for the activity measurement, allowing for a precise calibration of the dose calibrator and gamma-ray spectrometry of the two production sites. Each production site now has the capability of measuring 44Sc activity with an accuracy of 2%.
- Published
- 2023