1. Synthesis and Antimicrobial Evaluation of Some New Oxadiazoles Derived from Phenylpropionohydrazides
- Author
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Neeraj Kumar Fuloria, Mohammad Shaharyar, Mohammad Babar Ali, and Vijender Singh
- Subjects
Antifungal ,Azides ,medicine.drug_class ,Pharmaceutical Science ,Analytical Chemistry ,lcsh:QD241-441 ,chemistry.chemical_compound ,lcsh:Organic chemistry ,phenylpropionohydrazide ,Anti-Infective Agents ,Drug Discovery ,medicine ,Organic chemistry ,Molecule ,Physical and Theoretical Chemistry ,Oxadiazoles ,Molecular Structure ,Communication ,Organic Chemistry ,Antimicrobial ,Combinatorial chemistry ,Acetic anhydride ,antibacterial ,chemistry ,Chemistry (miscellaneous) ,imines ,Molecular Medicine ,antifungal - Abstract
In this study a series of new 1-(2-aryl-5-phenethyl-1,3,4-oxadiazol-3(2H)-yl)ethanones 2a-e was synthesized by the cyclization of imines 1a-e using acetic anhydride. The products were evaluated for anti-bacterial and anti-fungal activity. Among the newly synthesized compounds, 1-(2-(4-(dimethylamino)phenyl)-5-phenethyl-1,3,4-oxadiazol-3(2H)-yl)ethanone (2a) and 1-(2-(4-chlorophenyl)-5-phenethyl-1,3,4-oxadiazol-3(2H)-yl)ethanone (2b) were found to possess maximum activity against the tested strains of S. aureus and P. aeruginosa. It was concluded that para-substitution enhances the activity of synthesized oxadiazoles.
- Published
- 2009