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Start Over Author "Lakshmanan, Rajeswari" Publisher mjh life sciences
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1. Utilization of CESI Technology for Comprehensive Characterization of Biologies.

Author

Lakshmanan, Rajeswari

Subjects
*CAPILLARY electrophoresis, *ELECTROSPRAY ionization mass spectrometry, *MONOCLONAL antibodies, *TRASTUZUMAB, *GLYCOPEPTIDES
Abstract

The article focuses on the use of the CESI-MS, which is the integration of capillary electrophoresis (CE) and electrospray ionization (ESI) mass spectrometry (MS), for the characterization of monoclonal antibodies during their development. It mentions a study in which the monoclonal antibody Trastuzumab was alkylated and digested with trypsin and data from CESI-MS were analysed. It discusses the effectiveness of CESI-MS in the analysis of primary sequence coverage and glycopeptide profiling.

Published
2014

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