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Thus, the concept of normative uncertainty involves value-based considerations in those aspects of decision-making related to epistemology, ethics, law, and planning. As such, philosophy has much to add to our understanding of future risks in science and technology and, more specifically, the role of uncertainties. In this Special Issue, we will focus on the class that Rumsfeld calls I unknown unknowns i . This Special Issue titled "Severe Uncertainty in Science, Medicine and Technology" aims to shed new light on the understanding of severe uncertainty and its multifaceted implications. [Extracted from the article]