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39 results on '"Seth, Amlesh"'

7. Author Reply Re: Sharma PK, Panaiyadiyan S, Kurra S, Kumar R, Nayak B, Kaushal S, et al. Association of human papillomavirus in penile cancer: A single-center analysis. Indian J Urol 2022;38:210

Author

Singh, Prabhjot, primary, Sharma, PrashantKumar, additional, Panaiyadiyan, Sridhar, additional, Kurra, Santosh, additional, Kumar, Raman, additional, Nayak, Brusabhanu, additional, Kaushal, Seema, additional, Sharma, Alpana, additional, Kumar, Rajeev, additional, and Seth, Amlesh, additional

Published
2022
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8. Multiparametric magnetic resonance imaging, 68Ga prostate-specific membrane antigen positron emission tomography–Computed tomography, and respective quantitative parameters in detection and localization of clinically significant prostate cancer in intermediate- and high-risk group patients: An Indian demographic study

Author

Das, ChandanJyoti, primary, Kubihal, Vijay, additional, Sharma, Sanjay, additional, Kumar, Rakesh, additional, Seth, Amlesh, additional, Kumar, Rajeev, additional, Kaushal, Seema, additional, Sarangi, Jayati, additional, and Gupta, Ravikant, additional

Published
2021
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13. Author Reply Re: Bansal D, Nayak B, Singh P, Nayyar R, Ramachandran R, Kumar R, Seth A. Randomized controlled trial to compare outcomes with and without the enhanced recovery after surgery protocol in patients undergoing radical cystectomy. Indian J Urol 2020;36:95-100

Author

Nayak, Brusabhanu, primary, Bansal, Devanshu, additional, Singh, Prabhjot, additional, Nayyar, Rishi, additional, Ramachandran, Rashmi, additional, Kumar, Rajeev, additional, and Seth, Amlesh, additional

Published
2020
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14. Multiparametric magnetic resonance imaging, 68Ga prostate-specific membrane antigen positron emission tomography–Computed tomography, and respective quantitative parameters in detection and localization of clinically significant prostate cancer in intermediate- and high-risk group patients: An Indian demographic study

Author

Kubihal, Vijay, Sharma, Sanjay, Kumar, Rakesh, Seth, Amlesh, Kumar, Rajeev, Kaushal, Seema, Sarangi, Jayati, Gupta, Ravikant, and Das, Chandan Jyoti

Subjects
68Ga Prostate-specific membrane antigen positron emission tomography–computed tomography, quantitative magnetic resonance imaging parameters (apparent diffusion coefficient, Original Article, SUVmax, Radiology, Nuclear Medicine and imaging, clinically significant prostate cancer, urologic and male genital diseases, multiparametric magnetic resonance imaging, Ktrans, and Kep)
Abstract

Objectives: The objective of this study was to evaluate the diagnostic accuracy of multiparametric magnetic resonance imaging (mpMRI) and 68Ga prostate-specific membrane antigen positron emission tomography–computed tomography (PSMA PET-CT) and respective quantitative parameters (Ktrans – influx rate contrast, Kep – efflux rate constant, ADC – apparent diffusion coefficient, and SUVmax ratio – prostate SUVmax to background SUVmax ratio) in detection and localization of clinically significant prostate cancer (CSPCa) in D’Amico intermediate- and high-risk group patients (prostate-specific antigen [PSA] >10 ng/ml). Methodology: The study included thirty-three consecutive adult men with serum prostate specific antigen >10ng/ml, and systematic 12 core prostate biopsy proven prostate cancer. All the 33 patients, were evaluated with mpMRI, and 68Ga PSMA PET-CT. The biopsy specimens and imaging were evaluated for 12 sectors per prostate by a predetermined scheme. Results: MpMRI Prostate Imaging Reporting and Data System version 2 (PI-RADS v2) score ≥3 showed higher sensitivity than 68Ga PSMA PET-CT (96.3% vs. 82.4%), with similar specificity (54.5% vs. 54.5%) (n = 33 patients, 396 sectors). Combined use of MRI and 68Ga PSMA PET-CT in parallel increased sensitivity (99.5%) and NPV (98.7%) for detection of CSPCa and combined use of MRI and 68Ga PSMA PET-CT in series increased specificity (71.8%) and PPV (71.5%) (n = 33 patients, 396 sectors). ADC showed a strong negative correlation with Gleason score (r = −0.77), and the highest discriminative ability for detection and localization of CSPCa (area under curve [AUC]: 0.91), followed by Ktrans (r = 0.74; AUC: 0.89), PI-RADS (0.73; 0.86), SUVmax ratio (0.49; 0.74), and Kep (0.24; 0.66). Conclusion: MpMRI PI-RADS v2 score and 68Ga PSMA PET-CT (individually as well as in combination) are reliable tool for detection and localization of CSPCa. Quantitative MRI and 68Ga PSMA PET-CT parameters have potential to predict Gleason score and detect CSPCa.

Published
2021

27. Authors′ reply

Author

Gupta, NarmadaP, primary, Nayyar, Rishi, additional, Singh, Prabhjot, additional, Hemal, AshokK, additional, Dogra, PremN, additional, Seth, Amlesh, additional, and Kumar, Rajeev, additional

Published
2010
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38. Multiparametric Magnetic Resonance Imaging, 68 Ga Prostate-Specific Membrane Antigen Positron Emission Tomography-Computed Tomography, and Respective Quantitative Parameters in Detection and Localization of Clinically Significant Prostate Cancer in Intermediate- and High-Risk Group Patients: An Indian Demographic Study.

Author

Kubihal V, Sharma S, Kumar R, Seth A, Kumar R, Kaushal S, Sarangi J, Gupta R, and Das CJ

Abstract

Objectives: The objective of this study was to evaluate the diagnostic accuracy of multiparametric magnetic resonance imaging (mpMRI) and 68 Ga prostate-specific membrane antigen positron emission tomography-computed tomography (PSMA PET-CT) and respective quantitative parameters (K trans - influx rate contrast, K ep - efflux rate constant, ADC - apparent diffusion coefficient, and SUVmax ratio - prostate SUVmax to background SUVmax ratio) in detection and localization of clinically significant prostate cancer (CSPCa) in D'Amico intermediate- and high-risk group patients (prostate-specific antigen [PSA] >10 ng/ml)., Methodology: The study included thirty-three consecutive adult men with serum prostate specific antigen >10ng/ml, and systematic 12 core prostate biopsy proven prostate cancer. All the 33 patients, were evaluated with mpMRI, and 68 Ga PSMA PET-CT. The biopsy specimens and imaging were evaluated for 12 sectors per prostate by a predetermined scheme., Results: MpMRI Prostate Imaging Reporting and Data System version 2 (PI-RADS v2) score ≥3 showed higher sensitivity than 68 Ga PSMA PET-CT (96.3% vs. 82.4%), with similar specificity (54.5% vs. 54.5%) ( n = 33 patients, 396 sectors). Combined use of MRI and 68 Ga PSMA PET-CT in parallel increased sensitivity (99.5%) and NPV (98.7%) for detection of CSPCa and combined use of MRI and 68 Ga PSMA PET-CT in series increased specificity (71.8%) and PPV (71.5%) ( n = 33 patients, 396 sectors). ADC showed a strong negative correlation with Gleason score (r = -0.77), and the highest discriminative ability for detection and localization of CSPCa (area under curve [AUC]: 0.91), followed by K trans ( r = 0.74; AUC: 0.89), PI-RADS (0.73; 0.86), SUVmax ratio (0.49; 0.74), and K ep (0.24; 0.66)., Conclusion: MpMRI PI-RADS v2 score and 68 Ga PSMA PET-CT (individually as well as in combination) are reliable tool for detection and localization of CSPCa. Quantitative MRI and 68 Ga PSMA PET-CT parameters have potential to predict Gleason score and detect CSPCa., Competing Interests: There are no conflicts of interest., (Copyright: © 2021 Indian Journal of Nuclear Medicine.)

Published
2021
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39. Cutaneous metastasis of prostate carcinoma to neck and upper chest.

Author

Abrol N, Seth A, and Chattergee P

Subjects
Histocytochemistry, Humans, Immunohistochemistry, Male, Microscopy, Middle Aged, Neck pathology, Skin pathology, Thorax pathology, Adenocarcinoma pathology, Adenocarcinoma secondary, Prostatic Neoplasms diagnosis, Prostatic Neoplasms pathology, Skin Neoplasms pathology, Skin Neoplasms secondary
Abstract

Prostate adenocarcinoma is the most common urologic malignant neoplasm in men. Metastasis to skin is rarely reported and usually occurs late. The incidence and appearance of cutaneous metastasis are not well established in patients with prostate adenocarcinoma and their recognition remains poor among practicing urologists. Their clinical appearance may mimic other common dermatologic disorders. Definitive diagnosis requires a high index of suspicion. Immunohistochemical staining helps in establishing the diagnosis. We report a case of prostate adenocarcinoma presenting with widespread metastasis, including those to dermis and subcutaneous tissue of neck and upper chest.

Published
2011
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