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Your search keyword '"Sadasivam, Balakrishnan"' showing total 17 results
Start Over Author "Sadasivam, Balakrishnan" Publisher medknow
17 results on '"Sadasivam, Balakrishnan"'

1. Knowledge, attitude, and practice survey on antimicrobial use and resistance among Indian clinicians: A multicentric, cross-sectional study

Author

Chatterjee, Suparna, primary, Hazra, Avijit, additional, Chakraverty, Raja, additional, Shafiq, Nusrat, additional, Pathak, Ashish, additional, Trivedi, Niyati, additional, Sadasivam, Balakrishnan, additional, Kakkar, AshishKumar, additional, Jhaj, Ratinder, additional, Kaul, Rajni, additional, and Kshirsagar, Nilima, additional

Published
2022
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8. Organoids: An invaluable tool in pharmacology

Author

Avik Ray, Sadasivam Balakrishnan, Malaya Nanda, Shubham Atal, and C A Pravin

Subjects
Induced Pluripotent Stem Cells, Cell Culture Techniques, Normal tissue, Computational biology, Biology, Models, Biological, Drug Discovery, Organoid, three-dimensional, Animals, Humans, Pharmacology (medical), Precision Medicine, Induced pluripotent stem cell, Pharmacology, business.industry, Drug discovery, Stem Cells, Educational Forum, Disease progression, in vitro, Organoids, Multicellular organism, Drug screening, Personalized medicine, Stem cell, business
Abstract

Advances in stem cell cultures and human-induced pluripotent stem cells have inculcated interests in a rapidly evolving concept - "organoids." These are three-dimensional (3D) structures mimicking some of the phenomena of the real organs at anatomical, multicellular, and functional levels in vitro. Organoids have been proven to be better than two-dimensional cell culture in replicating the functionality, architectural, and geometrical features of tissues in vivo. Recent advancements have led to the generation of models for organ development and disease, finding applications in the drug discovery, screening of novel compounds, and personalized medicine. Since organoids follow the same natural pathway as the normal tissue or pathology, they can be used to study the expression of various genotypes and phenotypic variations across different species. In the light of these advancements, organoids are now being merged with bioengineering to come up with even better and reliable models to predict the disease progression and effectiveness of precision medicines, few of its important applications. This article discusses the various aspects of this emerging concept along with its uses, both in the present times and near future, with a special focus on pharmacological applications.

Published
2020
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14. COVID-19 and thrombotic complications-the role of anticoagulants, antiplatelets and thrombolytics.

Author

Khandelwal G, Ray A, Sethi S, Harikrishnan HK, Khandelwal C, and Sadasivam B

Abstract

Coronavirus disease 2019 (COVID-19) is a global pandemic the world is dealing with currently. Clinical evidences suggest that the patients are predisposed to both venous and arterial thrombotic complications. This is because of severe inflammatory responses, injury to endothelium and activation of platelets leading to increased coagulation. Additionally, individuals who are already receiving antithrombotic drug therapy for various cardiovascular diseases and complications might contract the disease in which case, attention should be given to the choice and duration of the therapy besides close monitoring of biochemical blood parameters. Herein, we review the incidences of thrombotic complications and their outcomes in COVID-19 patients as reported till date, while understanding the prophylactic and therapeutic roles of anticoagulants, antiplatelets and thrombolytics in the management of this severe viral respiratory illness., Competing Interests: There are no conflicts of interest., (Copyright: © 2021 Journal of Family Medicine and Primary Care.)

Published
2021
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15. How to choose and interpret a statistical test? An update for budding researchers.

Author

Najmi A, Sadasivam B, and Ray A

Abstract

Postgraduate medical students are often not able to select and interpret the findings of statistical tests during their thesis or research projects. To go ahead with selection of tests to be performed, researchers need to determine the objectives of study, types of variables, analysis and the study design, number of groups and data sets, and the types of distribution. In this review, we summarize and explain various statistical tests to help postgraduate medical students to select the most appropriate techniques for their thesis and dissertation., Competing Interests: There are no conflicts of interest., (Copyright: © 2021 Journal of Family Medicine and Primary Care.)

Published
2021
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