1. Effects of vitamin A, C and E, or omega-3 fatty acid supplementation on the level of paraoxonase and arylesterase activity in streptozotocin-induced diabetic rats: an investigation of activities in plasma, and heart and liver homogenates
- Author
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Mahnaz Zarei, Payam Farahbakhsh-Farsi, Ebrahim Mostafavi, Seyed Mohammad Bagher Tabei, Mohammad Hassan Javanbakht, Mohammad Reza Sadeghi, Hoda Derakhshanian, Mahmoud Djalali, and Shima Fakher
- Subjects
Male ,0301 basic medicine ,Vitamin ,medicine.medical_specialty ,medicine.medical_treatment ,Ascorbic Acid ,Diabetes Mellitus, Experimental ,Rats, Sprague-Dawley ,Arylesterase ,03 medical and health sciences ,chemistry.chemical_compound ,0302 clinical medicine ,Internal medicine ,Fatty Acids, Omega-3 ,medicine ,Animals ,Vitamin A ,Omega 3 fatty acid ,chemistry.chemical_classification ,Vitamin C ,biology ,Aryldialkylphosphatase ,business.industry ,Myocardium ,Vitamin E ,Paraoxonase ,Fatty acid ,Vitamins ,General Medicine ,Ascorbic acid ,Rats ,030104 developmental biology ,Endocrinology ,Liver ,chemistry ,030220 oncology & carcinogenesis ,Dietary Supplements ,biology.protein ,Original Article ,business ,Carboxylic Ester Hydrolases - Abstract
INTRODUCTION This study was designed and conducted to evaluate the effects of vitamin A, C and E supplementation, and omega-3 fatty acid supplementation on the activity of paraoxonase and arylesterase in an experimental model of diabetes mellitus. METHODS A total of 64 male Sprague Dawley® rats, each weighing 250 g, were randomly distributed into four groups: (a) normal control; (b) diabetic control; (c) diabetic with vitamin A, C and E supplementation; and (d) diabetic with omega-3 fatty acid supplementation. The animals were anaesthetised after four weeks of intervention, and paraoxonase and arylesterase activity in blood plasma, and liver and heart homogenates were measured. RESULTS Arylesterase activity in the heart and liver homogenates was significantly lower in the diabetic control group than in the normal control group (p < 0.01). Vitamin A, C and E supplementation, and omega-3 fatty acid supplementation significantly increased liver arylesterase activity (p < 0.05). No significant change was observed in paraoxonase activity and other investigated factors. CONCLUSION Vitamin A, C and E, or omega-3 fatty acid supplementation were found to increase liver arylesterase activity in streptozotocin-induced diabetic rats. These supplements may be potential agents for the treatment of diabetes mellitus complications.
- Published
- 2016