5 results on '"Mohsen Mahmoudieh"'
Search Results
2. Bone health after bariatric surgery: Consequences, prevention, and treatment
- Author
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Masood, Sayadi Shahraki, Mohsen, Mahmoudieh, Behrouz, Kalidari, Hamid, Melali, Maryam, Mousavi, Mohammad Raisi, Ghourban Abadi, Seyed Hossein, Mirhosseini, and Seyed Ali, Mirhosseini Dehabadi
- Subjects
General Medicine - Abstract
One of the most critical complications of bariatric surgery (BS), which has been widely discussed recently, is its adverse effects on the health of the bones and skeletal system. Studies show that bone mineral density (BMD) decreases significantly in the early years after BS Nutritional deficiencies are a common complication of BS that can last for months to years after surgery. For example, calcium absorption will significantly reduce after BS The role of gut hormones, endocrine factors, and adipokines in altering bone metabolism should never be overlooked. The available information and guidelines emphasize the periodic evaluation of BMD in patients undergoing BS The method of measuring BMD after BS is essential. DXA and quantitative computed tomography (QCT) are two convenient methods for measuring BMD. Many studies indicate a more detailed study of microarchitecture and cortical and trabecular bone mass with the help of QCT. The overall risk of fractures increases years after BS There are some recommendations for overcoming the adverse effects of BS on bone health. Endurance and resistance exercise after BS can help to mitigate BMD reduction and bone changes. In this review, we will explain each of these points in detail.
- Published
- 2022
3. Patients with Penetrating Abdominal Stab Wounds Which Require Laparotomy?
- Author
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Mohsen Mahmoudieh, Behnam Sanei, Shahab Shahabi Shahmiri, Hamid Talebzadeh, and Zahra Aghaei
- Subjects
medicine.medical_specialty ,medicine.diagnostic_test ,business.industry ,Exploratory laparotomy ,medicine.medical_treatment ,Abdominal fascia ,Critical Care and Intensive Care Medicine ,medicine.disease ,Surgery ,medicine.anatomical_structure ,Diagnostic peritoneal lavage ,Blunt trauma ,Laparotomy ,Medicine ,Abdomen ,Orthopedics and Sports Medicine ,business ,Stab wound ,Penetrating trauma - Abstract
Background The optimal management of hemodynamically stable asymptomatic patients with anterior abdominal stab wounds (AASWs) remains controversial. The goal is to identify and treat injuries in a safe cost-effective manner. Common evaluation strategies are local wound exploration (LWE), diagnostic peritoneal lavage (DPL), serial clinical assessment (SCAs) and computed tomography (CT) imaging. Making a decision about the right time to operate on a patient with a penetrating abdominal stab wound, especially those who have visceral evisceration, is a continuing challenge. Objectives Until the year 2010, our strategy was emergency laparotomy in patients with penetrating anterior fascia and those with visceral evisceration. This survey was conducted towards evaluating the results of emergency laparotomy. So, better management can be done in patients with penetrating abdominal stab wounds. Patients and Methods This retrospective cross-sectional study was performed on patients with abdominal penetrating trauma who referred to Al- Zahra hospital in Isfahan, Iran from October 2000 to October 2010. It should be noted that patients with abdominal blunt trauma, patients under 14 years old, those with lateral abdomen penetrating trauma and patients who had unstable hemodynamic status were excluded from the study. Medical records of patients were reviewed and demographic and clinical data were collected for all patients including: age, sex, mechanism of trauma and the results of LWE and laparotomy. Data were analyzed with PASW v.20 software. All data were expressed as mean ± SD. The distribution of nominal variables was compared using the Chi-squared test. Also diagnostic index for LWE were calculated. A two-sided P value less than 0.05 was considered to be statistically significant. Results During the 10 year period of the study, 1100 consecutive patients with stab wounds were admitted to Al-Zahra hospital Isfahan, Iran. In total, about 150 cases had penetrating traumas in the anterior abdomen area. Sixty-three (42%) patients were operated immediately due to shock, visceral evisceration or aspiration of blood via a nasogastric tube on admission. Organ injury was seen in 78% of patients with visceral evisceration. Among these 87 cases, 29 patients’ (33.3%) anterior fascia was not penetrated in LWE. So, they were observed for several hours and discharged from the hospital without surgery. While for the remaining 58 patients (66.6%), whose LWE detected penetration of anterior abdominal fascia, laparotomy was performed which showed visceral injuries in 11 (18%) cases. Conclusions All in all, 82 percent of laparotomies in patients with penetrated anterior abdominal fascia without visceral evisceration, who had no signs of peritoneal irritation, were negative. So, we recommended further evaluation in these patients. However, visceral evisceration is an indication for exploratory laparotomy, since in our study; the majority of patients had organ damages.
- Published
- 2013
4. Aspects of quality of life affected in morbidly obese patients who decided to undergo bariatric surgery: A qualitative study to design a native questionnaire
- Author
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Behrouz Keleidari, Behzad Zolfaghari, Samira Davashi Jamalouee, Mohsen Mahmoudieh, and Mahsa Gharzi
- Subjects
medicine.medical_specialty ,Short Communication ,lcsh:Medicine ,Morbidly obese ,Morbid obesity ,Psychological health ,03 medical and health sciences ,0302 clinical medicine ,Quality of life (healthcare) ,medicine ,030212 general & internal medicine ,Bariatric surgery ,030504 nursing ,business.industry ,questionnaire ,lcsh:R ,Physical health ,General Medicine ,medicine.disease ,Obesity ,morbid obesity ,Surgery ,quality of life ,Social relationship ,qualitative studies ,0305 other medical science ,business ,Qualitative research - Abstract
Background: Obesity is a known prevalent major health issue. The aim of this study is to assay Iranian patients' problems with obesity and their expectations of bariatric surgery. Materials and Methods: In this study, we included patients who have used different medical noninvasive treatments and were unsuccessful in losing weight from the obesity clinic in Al Zahra Hospital, Isfahan, from 2014 to 2015. Morbidly obese patients were interviewed using some open-ended questions, and then, directional content analysis of data was done. Results: Analysis of data showed five main categories including (1) physical health, (2) psychological health, (3) social relationships, (4) environment, and (5) “about the causes of obesity” with some subcategories for each category. Conclusion: This study is the first step of designing a quality of life questionnaire while we focused on spiritual and cultural states of Iranian people.
- Published
- 2017
5. The effect of adenosine A1 receptor agonist and antagonist on p53 and caspase 3, 8, and 9 expression and apoptosis rate in MCF-7 breast cancer cell line
- Author
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Mohammad Zamani Rarani, Mohsen Mahmoudieh, Mehdi Nikbakht Dastjerdi, and Ali Valiani
- Subjects
p53 ,0301 basic medicine ,Agonist ,medicine.drug_class ,Apoptosis ,Caspase 3 ,03 medical and health sciences ,Adenosine A1 receptor ,Pharmacy and materia medica ,0302 clinical medicine ,medicine ,MCF-7 cells ,Viability assay ,General Pharmacology, Toxicology and Pharmaceutics ,Receptor ,Caspase ,biology ,Chemistry ,Molecular biology ,RS1-441 ,030104 developmental biology ,Genes ,Adenosine A1 ,030220 oncology & carcinogenesis ,biology.protein ,Caspase 10 ,Original Article - Abstract
Adenosine receptor family especially A1 type is expressed in breast cancer cells in which P53 and caspase genes are wild-type. The aim of this study was to investigate the correlation between A1 receptor and either cell apoptosis or proliferation and also to recognize the relationship between this receptor and P53 and the expression of caspases 3, 8 and 9 in MCF-7 cell line. MCF-7 cells were treated intermittently with A1 receptor agonist N6-Cyclopentyladenosine (CPA) and A1 receptor antagonist 1,3-dipropyl-8-cyclopentylxanthine (DPCPX) in different times to measure the expression of p53, caspase 3, 8 and 9 besides apoptosis and survival rate. Our findings indicated that DPCPX significantly induced apoptosis in MCF-7 cells while the cell viability was reduced specially 72 h after the treatment and the expression of p53 gene and caspase expressions was dramatically up-regulated. On the other hand, CPA increased the cell viability and reduced apoptosis in MCF-7 cells. Our results indicated a significant down-regulation in the MCF-7 mRNA expression of p53 and caspases 3, 8 and 9. Furthermore, DPCPX induced p53 and caspase 3, 8 and 9 expressions that consequently promotes the cell apoptosis in MCF‑7 cells. Therefore, DPCPX can be considered as an anti-cancer drug.
- Published
- 2016
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