7 results on '"Krishnamachari Srinivasan"'
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2. Productivity losses among individuals with common mental illness and comorbid cardiovascular disease in rural Karnataka, India
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Fathima, FarahNaaz, primary, Kahn, JamesG, additional, Krishnamachari, Srinivasan, additional, and Ekstrand, Maria, additional
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- 2019
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Catalog
3. Downregulation of apolipoprotein A-IV in plasma & impaired reverse cholesterol transport in individuals with recent acts of deliberate self-harm
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Shakuntala Kandikuppa Murthy, Johnson Pradeep, Boby Mathew, Krishnamachari Srinivasan, Amit Kumar Mandal, and Tinku Thomas
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0301 basic medicine ,medicine.medical_specialty ,Apolipoprotein B ,030106 microbiology ,lcsh:Medicine ,Poison control ,Apolipoprotein A-IV ,General Biochemistry, Genetics and Molecular Biology ,03 medical and health sciences ,chemistry.chemical_compound ,0302 clinical medicine ,Western blot ,Internal medicine ,Medicine ,030212 general & internal medicine ,apolipoprotein a-iv - deliberate self-harm - esterified cholesterol - mass spectrometry - suicide - two-dimensional gel electrophoresis ,biology ,medicine.diagnostic_test ,business.industry ,Cholesterol ,lcsh:R ,Reverse cholesterol transport ,General Medicine ,Blood proteins ,Endocrinology ,chemistry ,biology.protein ,business ,Lipoprotein - Abstract
Background & objectives: The major limiting factor in the prevention of suicide is the limited knowledge on molecular insights in individuals at risk. Identification of peripheral protein markers which can classify individuals at high-risk of suicide might aid in early diagnosis and effective medical intervention. The aim of the present study was, therefore, to analyze the differential regulation of plasma proteins in individuals with deliberate self-harm compared to controls. Methods: Using two-dimensional gel electrophoresis coupled with matrix-assisted laser desorption-ionization mass spectrometry, differentially expressed plasma proteins were identified in study participants with deliberate self-harm compared to age- and gender-matched controls. The finding was validated using mass spectrometry-based isotope-labelled relative quantification and Western blot analysis in a new set of individuals with deliberate self-harm and controls. Results: The plasma proteomic analysis showed that apolipoprotein A-IV (Apo A-IV ) was downregulated by 2.63-fold (confidence interval: 1.52-4.54) in individuals with deliberate self-harm (n=10) compared to matched controls, which was consistent in mass spectrometry-based relative quantification and Western blot analysis performed in an independent set of individuals with deliberate self-harm (n=18). In addition, plasma levels of total cholesterol, esterified cholesterol and high-density lipoprotein (HDL) were observed to be significantly lower individuals with deliberate self-harm compared to controls. Interpretation & conclusions: Apo A-IV, which plays a crucial role in the esterification of free cholesterol, was found to be downregulated with concomitantly decreased levels of HDL, esterified cholesterol and total cholesterol in individuals with deliberate self-harm compared to matched controls. The present findings might provide a link between the differential regulation of plasma proteins and the previously reported results on altered cholesterol levels in individuals with deliberate self-harm. more...
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- 2019
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4. Elevated levels of glutathionyl haemoglobin as an oxidative stress marker in patients with major depressive disorder
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Tinku Thomas, Krishnamachari Srinivasan, Amit Kumar Mandal, Pradeep R Johnson, and Boby Mathew
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Adult ,Male ,0301 basic medicine ,Spectrometry, Mass, Electrospray Ionization ,medicine.medical_specialty ,030106 microbiology ,lcsh:Medicine ,medicine.disease_cause ,behavioral disciplines and activities ,Gastroenterology ,General Biochemistry, Genetics and Molecular Biology ,Hemoglobins ,03 medical and health sciences ,0302 clinical medicine ,Internal medicine ,mental disorders ,medicine ,Oxidative stress marker ,Humans ,In patient ,030212 general & internal medicine ,mass spectrometry ,Depressive Disorder, Major ,major depressive disorder ,business.industry ,lcsh:R ,Antidepressants ,General Medicine ,Middle Aged ,medicine.disease ,Glutathione ,Antidepressive Agents ,Pathophysiology ,Oxidative Stress ,Potential biomarkers ,Antidepressants - glutathionyl haemoglobin - major depressive disorder - mass spectrometry - oxidative stress ,Antidepressant ,Major depressive disorder ,Anxiety ,Original Article ,Female ,glutathionyl haemoglobin ,medicine.symptom ,business ,Biomarkers ,Selective Serotonin Reuptake Inhibitors ,Oxidative stress ,Chromatography, Liquid - Abstract
Background & objectives Oxidative stress has been implicated in the pathophysiology of major depressive disorder (MDD), but biomarkers to assess oxidative stress in patients with MDD have yielded ambiguous results. Glutathionyl haemoglobin (GS-Hb) has been reported as a stable and potential biomarker for oxidative stress in various clinical conditions. The objective of the study was to evaluate GS-Hb as a potential biomarker of oxidative stress in patients with MDD through its quantification and to compare the levels of GS-Hb in age- and gender-matched healthy controls. Methods The levels of GS-Hb were estimated using liquid chromatography coupled to electrospray ionization mass spectrometry in patients diagnosed with MDD and in a subset of patients after six weeks of treatment with selective serotonin reuptake inhibitors (SSRIs). Results GS-Hb levels in drug-naive patients with MDD (n=26) were significantly elevated compared to matched healthy controls (n=17). GS-Hb levels were not significantly different between MDD patients with and without co-morbid anxiety disorders. There were no significant differences in GS-Hb levels following six weeks of treatment with SSRIs compared to baseline. Interpretation & conclusions Compared to controls, GS-Hb level in patients with MDD was significantly elevated, suggestive of increased oxidative stress associated with MDD. However, six weeks of antidepressant treatment was not sufficient to modify the alterations in antioxidant/oxidant system. Further studies need to be done with a large sample of MDD patients with a longer duration of antidepressant treatment. more...
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- 2019
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5. Visceral artery pseudoaneurysm: A report of three cases
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Nelamangala Ramakrishnaiah, VishnuPrasad, primary, Kuppusamy, Sasikumar, additional, Krishnamachari, Srinivasan, additional, and Satheesh, Santosh, additional
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- 2015
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6. Clinico-epidemiological profile of tobacco users attending a tobacco cessation clinic in a teaching hospital in Bangalore city
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Dorothy P Rekha, Priya Sreedaran, Prem Mony, Krishnamachari Srinivasan, and George D'Souza
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Cessation ,lcsh:RC705-779 ,Pulmonary and Respiratory Medicine ,Pediatrics ,medicine.medical_specialty ,business.industry ,smokeless tobacco ,lcsh:Diseases of the respiratory system ,medicine.disease ,Nicotine replacement therapy ,tobacco ,smoking ,Sexual dysfunction ,Smokeless tobacco ,Concomitant ,Epidemiology ,Medicine ,Original Article ,Medical history ,Myocardial infarction ,clinic ,medicine.symptom ,business ,Stroke - Abstract
Background: Tobacco-attributable mortality in India is estimated to be at least 10%. Tobacco cessation is more likely to avert millions of deaths before 2050 than prevention of tobacco use initiation. Objective: To describe the clinico-epidemiological profile of attendees of a tobacco cessation clinic in a teaching hospital in Bangalore city. Materials and Methods: A descriptive study of 189 attendees seen over 2 years in the Tobacco Cessation Clinic of a tertiary-care teaching hospital in Bangalore, with information on socio demographic characteristics, tobacco-use details, nicotine dependence, family/medical history, past quit attempts, baseline stage-of-change, and treatment initiated. Results: Only 5% were ‘walk-in’ patients; 98% of attendees were smokers; 97% were males. The mean (±SD) age of attendees was 48.0 (±14.0) years. Most participants were married (88%), and predominantly urban (69%). About 62% had completed at least 8 years of schooling. Two-thirds of smokers reported high levels of nicotine dependence (Fagerström score >5/10). About 43% of patients had attempted quitting earlier. Four-fifths (79%) of tobacco-users reported a family member using tobacco. Commonly documented comorbidities included: Chronic respiratory disease (44%), hypertension (23%), diabetes (12%), tuberculosis (9%), myocardial infarction (2%), stroke (1%), sexual dysfunction (1%) and cancer (0.5%). About 52% reported concomitant alcohol use. At baseline, patients’ motivational stage was: Precontemplation (14%), contemplation (48%), preparation/action (37%) and maintenance (1%). Treatment modalities started were: Counseling alone (41%), nicotine replacement therapy alone (NRT) (34%), medication alone (13%), and NRT+medication (12%). Conclusions: This is the first study of the baseline profile of patients attending a tobacco cessation clinic located within a chest medicine department in India. Important determinants of outcome have been captured for follow-up and prospective documentation of outcomes. more...
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- 2012
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7. 'Blues' ain′t good for the heart
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Krishnamachari Srinivasan
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medicine.medical_specialty ,business.industry ,Unstable angina ,Hazard ratio ,medicine.disease ,Dysphoria ,Psychiatry and Mental health ,Internal medicine ,Relative risk ,medicine ,Cardiology ,Guest Editorial ,Myocardial infarction ,Risk factor ,medicine.symptom ,business ,Psychiatry ,Prospective cohort study ,Depression (differential diagnoses) - Abstract
Byline: Krishnamachari. Srinivasan Research in recent decades suggests that depression and coronary heart disease (CHD) have a bidirectional relationship. Depression, independent of other risk factors in an otherwise healthy person, doubles the risk of developing CHD. [sup][1] Depression is seen in about 20% of the patients hospitalized with acute coronary syndromes either at admission or in the immediate period following recovery from CHD. [sup][2] Depression in Patients with Coronary Heart Disease Cross-sectional studies have reported that between 19 and 66% of the patients with myocardial infarction (MI) have depressive and anxiety symptoms, [sup][3],[4] and a significant proportion of these patients (17-44%) are diagnosed with major depression. [sup][5],[6],[7] In addition, major depression is also common following coronary bypass surgery [sup][8] and in patients with unstable angina. [sup][9] Thus, these studies suggest that the prevalence rate of depression among patients with CHD is far greater than the 12-month prevalence rate of 6.6% reported in the community. [sup][10] Impact of Depression on Pre-Existing Coronary Heart Disease Over the last two decades, evidence has accumulated for the adverse impact of depression in patients with CHD. In one of the earliest studies in this area, Frasure Smith et al. [sup][11] in their study of depression and coronary heart disease in 222 patients post MI, those diagnosed with major depression on a modified version of the Diagnostic Interview Schedule had an adjusted hazard ratio of 3.44 (95% CI 2.25-4.63) for mortality over 6 months of follow-up compared with the controls. This was approximately equivalent to the risk engendered by clinical factors such as diminished left ventricular function and past history of MI. In a subsequent study, the same group of investigators followed-up this cohort over 18 months. [sup][12] Although baseline depression still predicted mortality at 18 months, its impact mainly occurred in the first 6 months. Similar findings of high mortality in subjects with unstable angina and comorbid depression have been reported. [sup][9] In addition, depression also has a negative impact on survival rates following coronary artery bypass graft (CABG). Two studies reported that the presence of depression at baseline prior to CABG was an independent predictor of cardiovascular mortality post-CABG. [sup][13],[14] There is also a dose-response relationship between depression and death due to adverse cardiac events, [sup][15] with increased baseline depression scores being associated with a higher risk of cardiac mortality. [sup][16] Depression and the Risk of Development of Coronary Heart Disease Several prospective studies have reported depression as a risk factor for the development of CHD, and this risk is independent of other cardiovascular risk factors. In a large prospective community-based study, patients with a history of dysphoria or depression had 4.5-times relative risk (RR) of having an acute MI compared with non-depressed subjects independent of other cardiovascular risk factors. [sup][17] It was also noted in this study that the risk of developing CHD was linked to the severity of depression, with an RR of 4.5 for developing CHD in subjects with major depression as opposed to 2.1 for subjects with dysphoria. A metaanalysis of studies in this area reported an RR of 1.64 for the development of CHD in subjects with depression. [sup][1] Pathophysiological Link between Depression and Coronary Heart Disease Depression and lifestyle behavior There exist several possible mechanisms that underlie the relationship between depression and CHD. Depression is associated with unhealthy lifestyle; depressed patients have a sedentary lifestyle, more likely to smoke and consume alcohol and are overweight/obese. [sup][18],[19],[20] Depression is also associated with non-compliance to medical treatment. … more...
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- 2011
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