1. Bilateral versus unilateral cryptorchidism in nonobstructive azoospermia: Testicular sperm extraction outcomes
- Author
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Nassima Ramdane, Agathe Dumont, Florence Boitrelle, Anaïs Dauvergne, G Robin, Valérie Mitchell, Anne-Laure Barbotin, Jean-Marc Rigot, Gamétogenèse et Qualité du Gamète - ULR 4308 (GQG), Université de Rouen Normandie (UNIROUEN), Normandie Université (NU)-Normandie Université (NU)-Université de Lille, Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Université de Picardie Jules Verne (UPJV), Université Paris Descartes - École de sages-femmes Baudelocque (UPD ESF Baudelocque), Université Paris Descartes - Paris 5 (UPD5), Unité de biostatistique, pôle de santé publique, CHRU de Lille, Département de biologie de la reproduction et de gynécologie [CHIPS, Poissy], centre hospitalier intercommunal de Poissy/Saint-Germain-en-Laye - CHIPS [Poissy], Service de Biostatistiques [CHRU Lille], Centre hospitalier intercommunal de Poissy/Saint-Germain-en-Laye - CHIPS [Poissy], Gamétogenèse et Qualité du Gamète (GQG), Normandie Université (NU)-Normandie Université (NU)-Université de Lille, Droit et Santé-Université de Lille, École de sages-femmes Baudelocque (ESF Baudelocque), and Département de biologie de la reproduction et de gynécologie [CHIPS, Poissy] [
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Adult ,Male ,endocrine system ,medicine.medical_specialty ,Sperm Retrieval ,Urology ,medicine.medical_treatment ,Population ,030232 urology & nephrology ,intracytoplasmic sperm injection ,Unilateral cryptorchidism ,Intracytoplasmic sperm injection ,03 medical and health sciences ,0302 clinical medicine ,nonobstructive azoospermia ,medicine ,Humans ,education ,Azoospermia ,Retrospective Studies ,education.field_of_study ,030219 obstetrics & reproductive medicine ,testicular sperm extraction ,business.industry ,[SDV.BDLR]Life Sciences [q-bio]/Reproductive Biology ,General Medicine ,Testicular sperm extraction ,Pregnancy rate ,Treatment Outcome ,Original Article ,Luteinizing hormone ,business ,cryptorchidism ,Spermatogenesis - Abstract
International audience; Cryptorchidism is one of the most frequent causes of nonobstructive azoospermia (NOA) in adulthood. Although it is well known that spermatogenesis is more impaired in bilateral than in unilateral cryptorchidism, previous studies have only described small cohorts or inhomogeneous population. Consequently, we analyzed a cohort of 225 men with only a history of cryptorchidism as sole etiopathogenetic factor for NOA, and compared testicular sperm extraction (TESE) outcomes between men with bilateral versus unilateral cryptorchidism. Our results show no difference in follicle-stimulating hormone (FSH) levels and testicular volumes between men with a history of bilateral cryptorchidism compared to unilateral cryptorchidism (median: 21.3 IU l-1 vs 19.3 IU l-1, P = 0.306; and 7.2 ml vs 7.9 ml, P = 0.543, respectively). In addition, sperm retrieval rates were similar (66.2% vs 60.0%, P = 0.353). Using multivariate analysis, we have found that only a low inhibin B level (above the assay's detection limit) was positively associated with successful sperm retrieval (P < 0.05). Regarding intracytoplasmic sperm injection outcomes, we found that cumulative pregnancy rate and live birth rate per cycle were not statistically different between the two groups (17.4% vs 27.8%, P = 0.070; and 16.1% vs 26.4%, P = 0.067, respectively). Unexpectedly, there was no significant difference in hormonal profiles (FSH, luteinizing hormone [LH], testosterone, and inhibin B levels) and TESE outcomes between unilateral versus bilateral cryptorchidism. This suggests that a history of unilateral cryptorchidism could reflect a bilateral testicular impairment. Interestingly, inhibin B level might be a predictor of successful TESE.
- Published
- 2019
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