1. [Immunogenetic criteria for prediction of mixed hepatitis A + B].
- Author
-
Bondarenko AL, Ustiuzhaninov VN, Vozhegova NP, and Strazhnikova GA
- Subjects
- Adolescent, Adult, Carrier State diagnosis, Carrier State immunology, Female, HLA-A Antigens immunology, HLA-B Antigens immunology, Hepatitis A complications, Hepatitis A diagnosis, Hepatitis B complications, Hepatitis B diagnosis, Humans, Male, Middle Aged, Prognosis, Young Adult, Hepatitis A immunology, Hepatitis B immunology, Immunogenetics methods
- Abstract
The investigation has revealed that mixed hepatitis A + B is a genetically determined disease. HLA-A10, B21, Cw2, Cw5, A10-A19, B8-B13, B21-B35, A3-B21, and A9-B21 are immunogenetic markers of this disease. The carriers of HLA-B21, Cw5, A3-B21, and A9-B21 and those of HLA-A10, A10-A19, and A10-B14 are at high risk for this infection among men and women, respectively. The findings of the distribution of HLA antigens and their combinations in mixed infection with hepatitis A and B viruses allow prediction of its occurrence (including the consideration of examinees' gender) which will assist in solving the matter of timely prophylaxis of this pathology.
- Published
- 2009