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Patients with different types of labio-maxillo-palatine clefts go through a lifelong series of multidisciplinary therapeutic procedures; this “journey” sometimes begins prenatally and extends into adulthood. Presurgical orthopedic treatment (PSO) is one of the first stages of this therapeutic plan. The nasoalveolar molding technique (NAM) is a new method of approach, from the field of pre-surgical orthopedics, instituted at a very young age (infant), and aims to reduce the initial severity, the level of alveolar cleft and/or the degree of nasal deformity. This approach enables the primary surgical restore of the nostril and lip to heal beneath minimum tension, thereby reducing scar formation and enhancing the esthetic result. The NAM technique is the non-surgical, passive method of bringing the gum and lip together by redirecting natural growth forces. NAM has been shown to be an effective adjunctive therapy for reducing pain, deformity and the level of soft tissue tearing before surgery. This paper reviews the basic principles of NAM therapy, the different types of devices used in this therapy, the protocol followed and a critical evaluation of the advantages and disadvantages of this technique. As an example, finally, we present the case of an infant with a unilateral labiomaxillary cleft, to which a NAM-type orthopedic device was applied with the aim of reducing tensions at the level of the tissues with the defect, to minimize the extent of the surgical intervention and to minimize the risk of postsurgical retractile scars. Worldwide, the authors of various studies agree on the positive outcome of NAM for better aesthetics after surgical repair of cleft lip and palate (DLP). However, what still remains, at this moment, unfounded equivocal is whether the pre-surgical reduction of the cleft sizes and the modeling manipulation of the nasal complex benefit our patients in the long term. Despite a relatively small amount of high-level evidence, NAM appears to be a promising technique that deserves further research. [ABSTRACT FROM AUTHOR]