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Introduction. The analysis of allergen-specific IgE responses in birth cohorts with micro-arrayed allergens has provided detailed information regarding the evolution of specific IgE responses in children. Data regarding early development of allergen-specific IgG are needed. Materials and method. We analyzed the results obtained by searching for keywords "maternal allergens", "specific IgG", and "sensibilization" in PubMed and Elsevier databases. There were identified a number of 1984 publications, of which we kept exclusively those in extenso describing results of randomized studies. The studies were analyzed in order to identify the following variables: specific IgG dosage of maternal allergen in the third trimester, the identification of IgG in cord blood, and allergic reactions of children at two months, six months, one year and at five years. Results and discussion. A number of two studies have identified the fact that all children from mothers with elevated (>30 ISU) specific plasma IgG against an allergen did not have IgE sensitization against that allergen at the age of 5 years old. Conclusions. The latest studies in the field have shown that high levels of IgG specific to allergen in mothers during the third trimester and in cord blood seem to protect against allergic sensitization in children. This finding has clinical implications for the prevention of allergies, as well as in their treatment. Studies on human subjects are limited, but the experimental ones are promising, more studies being needed on this topic. [ABSTRACT FROM AUTHOR]

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Allergic diseases, including allergic rhinitis/ rhinoconjuctivitis, asthma, and urticaria, are common conditions in the adult population, affecting women at the fertile age. Although, ideally, pregnant women should not receive pharmacologic treatment because of associated risks for the unborn child, sometimes quality of life impairment or risks of associated complications make medication necessary. The benefit/risk ratios associated with treatment in allergic diseases are favourable and allow the safe administration of several pharmacological classes. Oral antihistamines, predominantly loratadine and cetirizine, have a good safety profile in pregnant women. Treating asthma is extremely important because of the risks associated with the disease, and the preferred treatment is inhaled corticosteroids, and other classes of antiasthmatic drugs can also be administered. Allergen-specific immunotherapy can be continued during pregnancy safely, and some studies suggest a possible protective effect on the subsequent development of allergic diseases in the child. [ABSTRACT FROM AUTHOR]

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